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EC number: 231-912-9 | CAS number: 7778-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- A 90-day drinking water toxicity study in rats of the environmental contaminant ammonium perchlorate
- Author:
- Siglin JC, Mattie, DR, Dodd RD, Hildebrandt PK & Baker WH
- Year:
- 2 000
- Bibliographic source:
- Toxicol Sci. 2000, Sep; 57(1):61-74
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The induction of micronuclei was assessed in bone marrow PCEs taks from rats administered ammonium perchlorate in the drinking water for up to 90 days.
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Ammonium perchlorate
- EC Number:
- 232-235-1
- EC Name:
- Ammonium perchlorate
- Cas Number:
- 7790-98-9
- IUPAC Name:
- ammonium perchlorate
- Test material form:
- not specified
- Details on test material:
- Ammonium perchlorate (Aldrich); 99.8% purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Springborn Ohio
- Age at study initiation: 7 weeks
- Housing: individual
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 50 +/- 15
- Air changes (per hr): 12-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- Drinking water
- Details on exposure:
- Groups of 20 -30 rats per sex were administered ammonium perchlorate in the drinking water at target dose levels of 0, 0.1, 0.05, 0.2, 1.0 or 10.0 mg/kg bw/d. Animals were sacrificed at Day 14 (10/sex: all groups), Day 90 (10/sex: all groups) or following a 30 -day recovery period (Day 120; 0, 0.05, 1 and 10 mg/kg bw/d).
- Duration of treatment / exposure:
- Up to 90 days
- Frequency of treatment:
- Daily/continuous
- Post exposure period:
- Not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.1, 0.5, 0.2, 1, 10 mg/kg bw/d
Basis:
other: target dose level
- No. of animals per sex per dose:
- 20-30
- Control animals:
- yes
- Positive control(s):
- Positive control animals were administered a single intraperitoneal injection of cyclophosphamide at 20 mg/kg bw/d.
Examinations
- Tissues and cell types examined:
- Bone marrow polychromatic erythrocytes (PCEs)
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- No increase in the incidence of micronucleated cells was observed. PCE:NCE ratio was unaffected by treatment. Toxicity was limited to effects on throid (increased weight, histopathology) at the highest dose level; effects on TSH and thyroid hormones were apparent in all treated groups.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Administration of ammonium perchlorate in the drinking water at dose levels of up to 10 mg/kg bw/d for up to 90 days did not result in an increased incidence of micronucleated bone marrow polychromatic erythrocytes. - Executive summary:
The incidence of micronuclei in rat bone marrow polychromatic erythrocytes was investigated as part of a 90 -day toxicity study in which ammonium perchlorate was administered to rats in the drinking water at dose levels of up to 10 mg/kg bw/d for up to 90 days. No increase in the incidence of micronucleated cells was observed. PCE:NCE ratio was unaffected by treatment. Toxicity was limited to effects on throid (increased weight, histopathology) at the highest dose level; effects on TSH and thyroid hormones were apparent in all treated groups.
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