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EC number: 288-509-6 | CAS number: 85736-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation:
- not irritating in rabbits (OECD TG 404; GLP; RL1); undiluted test material applied to the intact skin of 3 animals for 4 hours; slight to moderate edema 3/3 animals, grade 1 edema still present after 8 d (end of observation period); as a tendency toward reversibility was noted, it is judged to be reversible
Eye irritation:
- not irritating in rabbits (OECD TG 405; GLP; RL1); undiluted test material applied to right eye of 3 animal, rinsed after 24 h; grade 1 conjunctival redness (1/3 animals after 1 h), grade 1 discharge (2/3 animals after 1 h)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- Adopted 21 May 81
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Lippische Versuchstierzucht, Hagemann GmbH & Co. KG, D-4932 Extertal
- Age at study initiation: 10 weeks
- Housing: individually
- Diet (e.g. ad libitum): conventional Iaboratory diet (mümmel z, ssniff/Soest), ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 2°C
- Humidity (%): 40 -50%
- Photoperiod (hrs dark / hrs light): 12/12
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: adjacent areas of untreated skin of each animal served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 h
- Observation period:
- 8 d
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: left flank
REMOVAL OF TEST SUBSTANCE
- Washing (if done): At the end of the exposure period, residual test substance was removed by water.
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) 1 h, 24, 48 and 72 hrs and at 8 d
SCORING SYSTEM:
- Draize scale - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Remarks:
- however, a tendency towards reversibility was noted
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 d
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, Isotridecyl Methacrylate is not a dermal irritant.
- Executive summary:
In a primary dermal irritation study according to OECD guideline 404 (1981), 3 male young adult New Zealand White rabbits were dermally exposed to 0.5 g of Isotridecyl Methacrylate (91.4%) for 4 hours. Animals then were observed for 9 days. Irritation was scored by the method of Draize.
Very slight erythema was observed for up to 48 h. Slight to moderate edema was observed in all three animals. Grade 1 edema was still present after 8 d. However, as a tendency toward reversibility was noted, it is judged to be reversible.
In this study, Isotridecyl Methacrylate is not a dermal irritant.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Reference
Score at time point / Reversibility |
Erythema |
Edema |
Max. score: 4 |
Max. score: 4 |
|
60 min |
1/0/1 |
3/1/2 |
24 h |
1/0/1 |
2/2/1 |
48 h |
1/0/0 |
1/2/1 |
72 h |
0/0/0 |
1/1/1 |
0 d |
Not recorded (reversible) |
0/1/0 |
Average 24h, 48h, 72h |
0.67/0/0.33 |
1.67/1.67/191.4% |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted 24 Feb. 87
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Lippische Versuchstierzucht, Hagemann GmbH & Co. KG, D- 4932 Extertal
- Age at study initiation: 10 weeks
- Housing: individually
- Diet (e.g. ad libitum): conventional laboratory diet (mümmel z, ssniff/Soest), ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18±2°C
- Humidity (%): 40 - 50%
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): after the 24 h observation, the corneas were examined with fluorescein
SCORING SYSTEM: Draize scale
TOOL USED TO ASSESS SCORE: ophthalmoscope / fluorescein - Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1-3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: #1-3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1-3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1-3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, Isotridecyl Methacrylate is not irritating to the eyes.
- Executive summary:
In a primary eye irritation study according to OECD Guideline 405 (1987) 0.1 mL of Isotridecyl Methacrylate (91.4%) was instilled into the conjunctival sac of the right eye of young adult New Zealand White rabbits. The eyes were rinsed after 24 h. Animals then were observed for 8 days. Irritation was scored by the method of Draize.
Grade 1 conjunctival redness was observed in 1/3 animals after 1 h, grade 1 discharge was observed in 2/3 animals after 1 h. No other reactions were noted.
In this study, Isotridecyl Methacrylate is not irritating to the eyes.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Reference
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae |
Chemosis |
Discharge
|
Max. score: 4 |
Max. score: 2 |
Max. score: 3 |
Max. score: 4 |
Max. score: 3 |
|
1 h |
0/0/0 |
0/0/0 |
0/0/1 |
0/0/0 |
1/0/1 |
24 h |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
48 h |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
72 h |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
8 d |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
Average 24h, 48h, 72h |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In a primary dermal irritation study according to OECD guideline 404 (1981), 3 male young adult New Zealand White rabbits were dermally exposed to 0.5 g of Isotridecyl Methacrylate (91.4%) for 4 hours. Animals then were observed for 9 days. Irritation was scored by the method of Draize.
Very slight erythema was observed for up to 48 h. Slight to moderate edema was observed in all three animals. Grade 1 edema was still present after 8 d. However, as a tendency toward reversibility was noted, it is judged to be reversible.
In this study, Isotridecyl Methacrylate is not a dermal irritant.
Eye irritation
In a primary eye irritation study according to OECD Guideline 405 (1987) 0.1 mL of Isotridecyl Methacrylate (91.4%) was instilled into the conjunctival sac of the right eye of young adult New Zealand White rabbits. The eyes were rinsed after 24 h. Animals then were observed for 8 days. Irritation was scored by the method of Draize.
Grade 1 conjunctival redness was observed in 1/3 animals after 1 h, grade 1 discharge was observed in 2/3 animals after 1 h. No other reactions were noted.
In this study, Isotridecyl Methacrylate is not irritating to the eyes.
Respiratory irritation
No data on the respiratory irritation of Isotridecyl Methacrylate are available.
There are no data gaps for the endpoint irritation/corrosion. No human information is available for this endpoint. However, there is no reason to believe that these results would not be applicable to humans.
Justification for classification or non-classification
Based on the available data, Isotridecyl Methacrylate does not need to be classified for eye irritation or skin irritation according to regulation (EC) 1272/2008. Thus, no labelling is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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