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EC number: 232-306-7 | CAS number: 8002-33-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental results of read across chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- WoE report is prepared based on short term toxicity to aquatic invertebrates studies
1 and 2 - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): Castor oil, sulfated
- Molecular formula: C57H101O18S3Na3
- Molecular weight: 1239.5749 g/mol
- Smiles notation: CCCCCCC(OS(=O)(=O)[O-])C/C=C\CCCCCCCC(=O)OCC(OC(=O)CCCCCCC/C=C\CC(OS(=O)(=O)[O-])CCCCCC)COC(=O)CCCCCCC/C=C\CC(OS(=O)(=O)[O-])CCCCCC.[Na+].[Na+].[Na+]
- InChI: 1S/C57H104O18S3.3Na/c1-4-7-10-31-40-51(73-76(61,62)63)43-34-25-19-13-16-22-28-37-46-55(58)70-49-54(72-57(60)48-39-30-24-18-15-21-27-36-45-53(75-78(67,68)69)42-33-12-9-6-3)50-71-56(59)47-38-29-23-17-14-20-26-35-44-52(74-77(64,65)66)41-32-11-8-5-2;;;/h25-27,34-36,51-54H,4-24,28-33,37-50H2,1-3H3,(H,61,62,63)(H,64,65,66)(H,67,68,69);;;/q;3*+1/p-3/b34-25-,35-26-,36-27-;;;
- Substance type: Organic
- Physical Appearance pale yellow liquid - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- 1. The stock solution 10 g/l was prepared by dissolving white powder in acetone. For a final concentration of 100 mg/l in the test solution the final stock solution was mixed in reconstituent water. It was possible to test at higher substance concentration due to the formation of precipitate.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain: Straus
- Source: Own breeding at University of Chemistry and Technology, Prague
- Age at study initiation (mean and range, SD): The animals used for the test shall be less than 24 h old and should not be first brood progeny
- Feeding during test: No feeding
ACCLIMATION - No data available
- Acclimation period:
- Acclimation conditions (same as test or not):
- Type and amount of food:
- Feeding frequency:
- Health during acclimation (any mortality observed): - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Post exposure observation period:
- ± 1 hr
- Test temperature:
- 1. 20±1°C
2. 20.4 to 20.7° C - pH:
- 1. Test: 7.9 (No changed during test)
Control: 8 (change to 7.9 during test)
Control + acetone: 8 (change to 7.9 during test)
2. 7.7 to 7.9 - Dissolved oxygen:
- higher than 7.9 mg/L at the end of test
- Nominal and measured concentrations:
- 0, 10 mg/l
- Details on test conditions:
- 1. TEST SYSTEM
- Test vessel: 50 ml glass vessel
- fill volume: 25 ml
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 5
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
Natural water (surface or ground water), reconstituted water or dechlorinated tap water are acceptable as culturing and dilution water if D. magna survives in it for the duration of the culturing, acclimation and testing without showing signs of stress. Waters in the range pH 6 to pH 9, with hardness between 140 mg/l and 275 mg/l (as CaCO3) are recommended.
As an example, the preparation of dilution water meeting the requirements is described below.
Dissolve known quantities of reagents in water. The dilution water prepared shall have a pH of 7.8 ± 0.5, a hardness of (225 ± 50) mg/l (expressed as CaCO3), a molar Ca + Mg ratio close to 4 + 1 and a dissolved oxygen concentration above 7 mg/l.
Prepare the solutions specified below:
- Calcium chloride solution: Dissolve 117.6 g of calcium chloride dihydrate (CaCl2.2H2O) in water (4.2) and make up to 1 l with water (4.2).
- Magnesium sulfate solution: Dissolve 49.3 g of magnesium sulfate heptahydrate (MgSO4.7H2O) in water (4.2) and make up to 1 l with water (4.2).
- Sodium bicarbonate solution: Dissolve 25.9 g of sodium bicarbonate (NaHCO3) in water (4.2) and make up to 1 l with water (4.2).
- Potassium chloride solution: Dissolve 2.3 g of potassium chloride (KCI) in water (4.2) and make up to 1 l with water (4.2).
Mixing
Mix 2.5 ml of each of the four solutions and make up to 1 l with water.
The dilution water shall be aerated until the dissolved oxygen concentration has reached saturation and the pH has stabilized. If necessary, adjust the pH to 7.8 ± 0.5 by adding sodium hydroxide (NaOH) solution or hydrochloric acid (HCI). The dilution water prepared in this way shall not be further aerated before use.
- Sodium hydroxide solution, e.g. [NaOH] : 1 mol/l.
- Hydrochloric acid, e.g. [HCl] : 1 mol/l.
Reference substance:
Dissolve 600 mg of potassium dichromate (K2Cr2O7) in water and make up to 1 l with water (4.2).
OTHER TEST CONDITIONS
- Adjustment of pH: no adjustment done
- Photoperiod: No - Darkness
- Light intensity:
CALCULATION:
EC50 was calculated using non linear regression by the software Prism 4.0 - Reference substance (positive control):
- yes
- Remarks:
- 1. Potassium dichromate (K2Cr2O7)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: IC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 1: 4 % inhibition were observed
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Other details not known
- Results with reference substance (positive control):
- 1. - Results with reference substance valid
- EC50: 0.73 mg/L (24 hours) - Validity criteria fulfilled:
- not specified
- Conclusions:
- 1. As the chemical was not highly soluble in water thus test conducted at 10 mg/l. After the exposure of 48 hrs, only 4 % immobility were observed in Daphnia magna. Thus on that criteria chemical was not consider as toxic. Based on the study chemical was may be consider as nontoxic and notclassified as per the CLP criteria.
2. Based on the immobility of daphnia magna by providing the exposure of test chemical for 48 hrs, the EC50 was determine to be > 5 mg/l.
On the basis of the experimental studies and all the data summarized for Castor oil, sulfated (8002-33-3), it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria. - Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity to aquatic invertebrates of the test chemical Castor oil, sulfated. The studies are as mentioned below:
Aim of this study was to assess the short term toxicity of to test chemical to aquatic invertebrate daphnia magna. Study was performed according to the OECD guideline 202 in a static system for the total exposure period of 48 hrs. The stock solution 10 g/l was prepared by dissolving white powder in acetone. For a final concentration of 100 mg/l in the test solution the final stock solution was mixed in reconstitute water. It was possible to test at higher substance concentration due to the formation of precipitate. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. As the chemical was not highly soluble in water thus test conducted at 10 mg/l. After the exposure of 48 hrs, only 4 % immobility were observed in Daphnia magna. Thus on that criteria chemical was not consider as toxic. Based on the study chemical was may be consider as nontoxic and not classified as per the CLP criteria.
Similarly another study was conducted to evaluate the effect of test chemical on the mobility of daphnia magna by providing the exposure period of 48 hrs. Test conducted in accordance with the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Study performed under the static system. Based on the immobility of daphnia magna by providing the exposure of test chemical for 48 hrs, the EC50 was determine to be > 5 mg/l. As the chemical was readily degradable in water thus before causing any toxicity on the daphnia and other aquatic invertebrates it degrades. Thus on the overall criteria chemical was consider as nontoxic and not classified as per the CLP classification criteria.
On the basis of the experimental studies and all the data summarized for Castor oil, sulfated (8002-33-3), it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
Reference
Description of key information
1. As the chemical was not highly soluble in water thus test conducted at 10 mg/l. After the exposure of 48 hrs, only 4 % immobility were observed in Daphnia magna. Thus on that criteria chemical was not consider as toxic. Based on the study chemical was may be consider as nontoxic and notclassified as per the CLP criteria.
2. Based on the immobility of daphnia magna by providing the exposure of test chemical for 48 hrs, the EC50 was determine to be > 5 mg/l.
On the basis of the experimental studies and all the data summarized for Castor oil, sulfated (8002-33-3), it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
Key value for chemical safety assessment
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity to aquatic invertebrates of the test chemical Castor oil, sulfated. The studies are as mentioned below:
Study from experimental study report 2017, Aim of this study was to assess the short term toxicity of to test chemical to aquatic invertebrate daphnia magna. Study was performed according to the OECD guideline 202 in a static system for the total exposure period of 48 hrs. The stock solution 10 g/l was prepared by dissolving white powder in acetone. For a final concentration of 100 mg/l in the test solution the final stock solution was mixed in reconstitute water. It was possible to test at higher substance concentration due to the formation of precipitate. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. As the chemical was not highly soluble in water thus test conducted at 10 mg/l. After the exposure of 48 hrs, only 4 % immobility were observed in Daphnia magna. Thus on that criteria chemical was not consider as toxic. Based on the study chemical was may be consider as nontoxic and not classified as per the CLP criteria.
Similarly another study from authoritative database was conducted to evaluate the effect of test chemical on the mobility of daphnia magna by providing the exposure period of 48 hrs. Test conducted in accordance with the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Study performed under the static system. Based on the immobility of daphnia magna by providing the exposure of test chemical for 48 hrs, the EC50 was determine to be > 5 mg/l. As the chemical was readily degradable in water thus before causing any toxicity on the daphnia and other aquatic invertebrates it degrades. Thus on the overall criteria chemical was consider as nontoxic and not classified as per the CLP classification criteria.
On the basis of the experimental studies and all the data summarized for Castor oil, sulfated (8002-33-3), it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
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