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EC number: 219-145-8 | CAS number: 2372-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 21, 2002 to March 27, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- Cited as Directive 84/449/EEC, C.10
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Sterile test buffer solutions of pH 4.0, 7.0 and 9.0 were prepared and purged with nitrogen. The bottles were tightly closed and placed in a thermostatically controlled waterbath at 50 ± 0.5°C in the dark. When the buffer solutions had equilibrated with the temperature of the waterbath the test substance was added and the pH was checked.
The concentration of the test substance in the buffer solutions did not exceed 0.01 M or its half-saturation concentration in water. A final concentration of about 300 mg/L was obtained by adding 5 mL stock solution of test substance to 1000 mL of test buffer solution for each pH.
At each sampling time about 25 mL of sample was taken and transferred into a 30 mL sample vial. To the samples of buffer pH 4 400 µL of 5 M NaOH was added, to the samples of buffer pH 7 250 µL of 5M NaOH was added and to the samples of buffer pH 9 200 µL of 5 M NaOH was added. The samples were stored in refrigerator until they were subjected to the analytical procedure. The temperature of the thermostatic waterbath was checked at least at the start and end of the tests and at each sampling time.
The test at pH 4 was repeated using a buffer, which did not interact with the test substance. During the first test at pH 4 a precipitate was detected in the test buffer. During this test two samples of 25 mL were taken at the beginning of the test and two at the end of the test. At each sample 1 mL of 5M NaOH was added. The samples were stored in refrigerator until they were subjected to the analytical procedure. The temperature of the thermostatic waterbath was checked at least at the start and end of the tests and at each sampling time. - Buffers:
- - pH 4: Composition of buffer: 50 mL 0.5M Boric acid and 50 mL 0.5M Potassium chloride diluted to 500 mL with deionized water
- pH 7: Composition of buffer: 50 mL 0.5M Potassium dihydrogen phosphate and 2.96 mL 5 M NaOH and diluted to 500 mL with deionized water
- PH 9: Composition of buffer: 50 mL 0.5M Boric acid and 50 mL 0.5M Potassium chloride and 2.16 mL 5 M NaOH and diluted to 500 mL with deionized water
pH of buffer solutions were measured at 50 °C using a pH meter and adjusted with 0.5 M HCl or 0.5 M NaOH.
All chemicals used were of reagent grade. Only the potassium chloride was from Baker grade quality (assay 99.0 – 100.5%) and sodium hydroxide was from Fluka, purum p.a. quality (≥ 97%). - Estimation method (if used):
- Not applicable
- Details on test conditions:
- TEST TYPE: EEC Directive 92/69/EEC C.7 "Degradation: Abiotic Degradation: Hydrolysis as a Function of pH".
- Test medium: Deionized water
- Test system: The study was conducted in air-tight glass vessels. Thermostatic water bath with lid so that the vessels are placed in the dark,
calibrated thermometer, pH meter (Consort P501 Salm en Kipp bv, Breukelen, The Netherlands).
- Concentration of test substance: 300 mg a.i. /L
DURATION: 5 days (Tier 1)
REFERENCE SUBSTANCE: No
CONTROLS: None
Analytical determinations are done by gas chromatography. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 271.1 other: mg/g
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 312.1 other: mg/g
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 285.6 other: mg/g
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- preliminary test was performed to find a suitable buffer system causing no precipitation.
- Transformation products:
- no
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Details on results:
- The hydrolytic stability was determined at pH 4, 7 and 9. The results of the first preliminary tests at pH 4, 7 and 9 and the results of the second preliminary test at pH 4 are presented in Tables 1 to 4. A second test at pH 4 was performed because a precipitate was formed during the test with the test buffer at pH 4. Due to this precipitate a decrease of 70% of Dodecyl dipropylene triamine was detected. The second preliminary test at pH 4 using a buffer, which did not interact with the test substance showed no significant decrease of Dodecyl dipropylene triamine.
The peak of Dodecyl dipropylene triamine in the GC chromatogram found at about 6.2 minutes was used for interpretation of the hydrolysis rate. The decrease of the area of this peak was less than 4% after five days at all three pH values tested indicating that no hydrolyses occurred. Therefore, it can be concluded that Dodecyl dipropylene triamine is hydrolytically stable with a half-life equal to or greater than a year at pH 4, 7 and 9 at 25°C.
According to the results of the preliminary tests no further tests were necessary. - Results with reference substance:
- -
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the test substance was considered to be hydrolytically stable with a half-life (DT50) equal to or greater than one year at pH 4, 7 and 9 at 50°C.
- Executive summary:
A study was conducted to determine the hydrolysis of the test substance according to EU Method C7, in compliance with GLP. Approximately 300 mg/L of the test substance was placed in air-tight glass vessels in the dark for 5 d and the hydrolytic stability was determined at pH 4, 7 and 9. Less than 10% disappearance was observed at all pH conditions after 5 d at 50°C. Under the study conditions, the test substance was considered to be hydrolytically stable with a half-life (DT50) equal to or greater than one year at pH 4, 7 and 9 at 50°C (van Haperen, 2002).
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 200 other: µg/mL
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 200 other: µg/mL
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 200 other: µg/mL
- Transformation products:
- no
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the test substance did not hydrolyse, therefore any toxicological or ecotoxicological effects of the test substance were not a consequence of hydrolytic degradation products.
- Executive summary:
A study was conducted to determine the hydrolysis rate of the test substance according to EU Method C.7, in compliance with GLP. Degradation was measured at pH 4, 7 and 9. The test substance concentration and temperature were stable: 200 µg/mL and 50°C, respectively. Under the study conditions, the substance did not hydrolyse, with an estimated DT50 of more than one year (Howes, 1996).
Referenceopen allclose all
After 5 d at 50°C less than 10% decrease in test substance concentration was measured at all three pH values. It is therefore concluded that the test substance is hydrolytically stable with a half-life equal to or greater than one year at pH 4, 7 and 9 at ambient temperatures. During the first test with the test buffer at pH 4 a precipitate was formed. Due to this precipitate a decrease of 70% of dodecyl dipropylene triamine was detected. Therefore, a second test at pH 4 was performed using a buffer, which did not interact with the test substance. DT50 = equal to or greater than one year.
Table 1
Results of the first preliminary test; concentration of Dodecyl dipropylene triamine with the
standard deviation of the duplo analysis and the decrease of the test substance during the test at pH 4 and 50°C.
Sampling time (minutes) |
Average Dodecyl dipropylene triamine concentration |
STDEV |
Decrease |
|
(mg/g) |
|
(%) |
5 |
249.2 |
3.2 |
|
7252 |
74.1 |
0.4 |
70.3 (precipitation) |
Table 2
Results of the second preliminary test; concentration of Dodecyl dipropylene triamine with the standard
deviation of the duplo analysis and the decrease of the test substance during the test at pH 4 and 50°C.
Sampling time (minutes) |
Average Dodecyl dipropylene triamine concentration |
STDEV |
Decrease |
|
(mg/g) |
|
(%) |
5 |
271.1 |
1.8 |
|
7230 |
279.0 |
1.4 |
-2.9 |
Table 3
Results of the preliminary test; concentration of Dodecyl dipropylene triamine with the
standard deviation of the duplo analysis and the decrease of the test substance during the test at pH 7 and 50°C.
Sampling time (minutes) |
Average Dodecyl dipropylene triamine concentration |
STDEV |
Decrease |
|
(mg/g) |
|
(%) |
10 |
312.1 |
2.6 |
|
7255 |
312.7 |
2.8 |
-0.2 |
Table 4
Results of the preliminary test; concentration of Dodecyl dipropylene triamine
with the standard deviation of the duplo analysis and the decrease of the test substance during the test at pH 9 and 50°C.
Sampling time (minutes) |
Average Dodecyl dipropylene triamine concentration |
STDEV |
Decrease |
|
(mg/g) |
|
(%) |
5 |
285.6 |
1.5 |
|
7223 |
274.4 |
0 |
3.9 |
Table 5
pH and temperature ranges during hydrolysis tests.
Nominal pH |
Nominal temp. (°C) |
Initial pH |
Final pH |
Measured temp.range (°C) |
4 (first test) |
49.9 |
4.03 |
3.97 |
49.8 – 49.9 |
4 (second test) |
49.9 |
4.02 |
3.97 |
49.8 – 50.0 |
7 |
49.9 |
7.04 |
6.99 |
49.8 – 49.9 |
9 |
49.9 |
9.04 |
9.05 |
49.8 – 49.9 |
Description of key information
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 50 °C
Additional information
A study was conducted to determine the hydrolysis of the test substance according to EU Method C7, in compliance with GLP. Approximately 300 mg/L of the test substance was placed in air-tight glass vessels in the dark for 5 d and the hydrolytic stability was determined at pH 4, 7 and 9. Less than 10% disappearance was observed at all pH conditions after 5 d at 50°C. Under the study conditions, the test substance was considered to be hydrolytically stable with a half-life (DT50) equal to or greater than one year at pH 4, 7 and 9 at 50°C (van Haperen, 2002).
A study was conducted to determine the hydrolysis rate of the test substance according to EU Method C.7, in compliance with GLP. Degradation was measured at pH 4, 7 and 9. The test substance concentration and temperature were stable: 200 µg/mL and 50°C, respectively. Under the study conditions, the substance did not hydrolyse, with an estimated DT50 of more than one year (Howes, 1996).
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