Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-997-3 | CAS number: 504-63-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor starting point:
- NOAEC
- Value:
- 1 800 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 900 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Description: Relevant dose-descriptor inhalation
Value: NOAEL: 1800 mg/m3
Remark: This is the concentration where no adverse effects were seen in an extended repeated dose inhalation study.
Description: Modification of starting point for exposure time (inhalation)
Value: 2
Remark: Workers are assumed to have 8 hours of exposure 6/8 hours.
Description: Modification of starting point for differences in respiratory volumes
Value: factored into the value 2 above
Remark: Respiratory rate is higher (6.7/10 m3) for worker doing light activity relative to the resting state for the rats in the study.
- AF for dose response relationship:
- 1
- Justification:
- The robust database supports the confidence in the dose descriptor.
- AF for differences in duration of exposure:
- 6
- Justification:
- Appropriate AF for 2-week inhalation study to chronic exposure. Value adopted per REACH guidance R.8.4.3.1.
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- A default factor of 2.5 is appropriate per REACH guidance R.8.4.3.1 for inhalation.
- AF for intraspecies differences:
- 5
- Justification:
- This is a default assessment factor for the general population per REACH Guidance R.8.4.3.1 for inhalation.
- AF for the quality of the whole database:
- 1
- Justification:
- A high quality, robust toxicity database exists for this substance.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 200 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
This is a dose derived from the concentration where no adverse effects were seen in an extended oral study.
- AF for dose response relationship:
- 1
- Justification:
- The robust database supports the confidence in the dose descriptor.
- AF for differences in duration of exposure:
- 2
- Justification:
- A value of 2 was assigned for dermal based on oral subchronic (assumes 100% absorption dermally).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- A value of 1.0 was assigned for dermal because of low skin penetration potential and no differences in effect between rat and human, and mechanism and kinetics do not apply.
- AF for intraspecies differences:
- 2.5
- Justification:
- A value of 2.5 was assigned for dermal because halving the default value is still conservative based on low variability among humans in skin patch test.
- AF for the quality of the whole database:
- 1
- Justification:
- A high quality, robust toxicity database exists for this substance.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
This is a colourless and odourless liquid and exposure is most likely via the dermal route for workers but can conceivably occur by the inhalation route if aerosolization occurs. Therefore, DNELs for the dermal and inhalation routes of exposure have been determined but not for the oral route of exposure.
No local effects are expected from any route of exposure and no DNELs were derived for local effects.
This substance is not classified for acute or repeated exposure toxicity.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEC
- Value:
- 1 800 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 450 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Description: Relevant dose-descriptor inhalation
Value: NOAEL: 1800 mg/m3
Remark: This is the concentration where no adverse effects were seen in an extended repeated dose inhalation study.
Description: Modification of starting point for exposure time (inhalation)
Value: 4 general population (inhalation)
Remark: Exposure in the animal study was for 6 hours/day while the general population is assumed to be exposed as long as 24 hours/day (6/24 = 0.25 or an AF=4).
Description: Modification of starting point for differences in respiratory volumes (inhalation)
Value: 1
Remark: Respiratory rate is resting for rats on study and general population.
- AF for dose response relationship:
- 1
- Justification:
- The robust database supports the confidence in the dose descriptor.
- AF for differences in duration of exposure:
- 6
- Justification:
- Appropriate AF for 2-week inhalation study to chronic exposure.
- AF for other interspecies differences:
- 2.5
- Justification:
- A default factor of 2.5 is appropriate per REACH guidance R.8.4.3.1.
- AF for intraspecies differences:
- 10
- Justification:
- This is a default assessment factor for the general population per REACH Guidance R.8.4.3.1.
- AF for the quality of the whole database:
- 1
- Justification:
- A high quality, robust toxicity database exists for this substance.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 100 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Description: Relevant dose-descriptor dermal
Value: NOAEL: 1000 mg/kg-bw/day
Remark: This is a dose derived from the concentration where no adverse effects were seen in an extended oral study.
- AF for dose response relationship:
- 1
- Justification:
- The robust database supports the confidence in the dose descriptor.
- AF for differences in duration of exposure:
- 2
- Justification:
- Value adopted per REACH guidance R.8.4.3.1 the dermal default factor applies to an extrapolation from 90-day oral toxicity study to chronic no effect level.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Effect by this route is not dependent on metabolic rate.
- AF for other interspecies differences:
- 1
- Justification:
- For dermal exposure, no differences in susceptibility between rat and human were observed in dermal studies.
- AF for intraspecies differences:
- 5
- Justification:
- This is a default assessment factor for the general population per REACH Guidance R.8.4.3.1. Human repair-insult patch test results suggest no systemic toxic absorption and intraspecies variability for up to 75% of the substance by this route of exposure; reducing the default assessment factor by half is still conservative.
- AF for the quality of the whole database:
- 1
- Justification:
- A high quality, robust toxicity database exists for this substance.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Description: Relevant dose-descriptor oral
Value: NOAEL: 1000 mg/kg-bw/day
Remark: This is a dose derived from the concentration where no adverse effects were seen in an extended oral study.
- AF for dose response relationship:
- 1
- Justification:
- The robust database supports the confidence in the dose descriptor.
- AF for differences in duration of exposure:
- 2
- Justification:
- Value adopted per REACH guidance R.8.4.3.1 the oral and dermal default factor applies to an extrapolation from 90-day oral toxicity study to chronic no effect level.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Scaling factor for oral based on differences in default metabolic rates.
- AF for other interspecies differences:
- 2.5
- Justification:
- A default factor of 2.5 is appropriate per REACH guidance R.8.4.3.1.
- AF for intraspecies differences:
- 10
- Justification:
- This is a default assessment factor for the general population per REACH Guidance R.8.4.3.1.
- AF for the quality of the whole database:
- 1
- Justification:
- A high quality, robust toxicity database exists for this substance.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
This is a colourless and odourless liquid intended for many different endpoint uses including personal care products and cosmetics, and exposure may occur by the oral, dermal, and inhalation routes of exposure for the general population. Therefore, DNELs for all three routes of exposure have been derived for the general population
No local effects are expected from any route of exposure and no DNELs were derived for local effects.
This substance is not classified for acute or repeated exposure toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.