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EC number: 207-997-3 | CAS number: 504-63-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- PDO from chemical process.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Exposure was 24 hours rather than 4 hours. Readings were not made at 48 hours or 7 days. Exposure was occlusive not semi-occlusive.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propane-1,3-diol
- EC Number:
- 207-997-3
- EC Name:
- Propane-1,3-diol
- Cas Number:
- 504-63-2
- Molecular formula:
- C3H8O2
- IUPAC Name:
- propane-1,3-diol
- Details on test material:
- - Name of test material (as cited in study report): Propanediol-1,3
- Purity: Not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Adult
- Weight at study initiation: Not reported
- Housing: Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL
Twenty four hours prior to applying the material, the hair was removed from the backs of the animals with an electric clipper. - Duration of treatment / exposure:
- 24 hours
- Observation period:
- Skin reactions were evaluated upon removal of the patch. A second reading was made 48 hours later (72 hours after application).
- Number of animals:
- 12 rabbits - 6 treated on intact skin and 6 treated on abraded skin.
- Details on study design:
- TEST SITE
- Area of exposure: Patch measuring 1 inch x 1 inch
- Type of wrap if used: Patches were fixed to the application site by means of adhesive tape and the entire trunk of the rabbits were wrapped in impervious material to maintain the test patches in position.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
- Time after start of exposure: 24 hours
Evaluation of test sites was conducted by the method of Draize.
SCORING SYSTEM: Draize and CIVO
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- other: average
- Time point:
- other: 24 and 72 hours
- Score:
- >= 0.3 - <= 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 2
- Max. score:
- 4
- Remarks on result:
- other: 24 hours: erythema score was 2 for both intact and abraded skin 72 hours: erythema score was 1 for both intact and abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 2
- Max. score:
- 4
- Remarks on result:
- other: 24 hours: erythema score was 2 for intact skin and 1 for abraded skin 72 hours: erythema score was 1 for both intact and abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1
- Max. score:
- 4
- Remarks on result:
- other: 24 hours: erythema score was 1 for both intact and abraded skin 48 hours: erythema score was 0 for both intact and abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 2
- Max. score:
- 4
- Remarks on result:
- other: 24 hours: erythema score was 1 for intact skin and 2 for abraded skin 48 hours: erythema score was 0 for intact skin and 1 for abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1
- Max. score:
- 4
- Remarks on result:
- other: 24 hours: erythema score was 1 for both intact and abraded skin 48 hours: erythema score was 0 for intact skin and 1 for abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1
- Max. score:
- 4
- Remarks on result:
- other: 24 hours: erythema score was 1 for both intact and abraded skin 48 hours: erythema score was 0 for intact skin and 1 for abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: readings taken at 24 and 72 hours only
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: readings taken at 24 and 72 hours only
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: readings taken at 24 and 72 hours only
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: readings taken at 24 and 72 hours only
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: readings taken at 24 and 72 hours only
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: readings taken at 24 and 72 hours only
- Irritant / corrosive response data:
- The test substance casued very sight or well-defined erythema of the treated skin of rabbits.
Any other information on results incl. tables
Animal Number |
Intact Skin |
Animal Number |
Abraded skin |
||
24 Hours A B |
72 Hours A B |
24 Hours A B |
72 Hours A B |
||
8328 |
2-0 |
1-0 |
8322 |
2-0 |
1-0 |
8329 |
2-0 |
1-0 |
8323 |
1-0 |
1-0 |
8330 |
1-0 |
0-0 |
8324 |
1-0 |
0-0 |
8331 |
1-0 |
0-0 |
8325 |
2-0 |
1-0 |
8332 |
1-0 |
0-0 |
8326 |
1-0 |
1-0 |
8333 |
1-0 |
0-0 |
8327 |
1-0 |
1-0 |
|
|
|
|
|
|
Average |
1.3 |
0.3 |
|
1.3 |
0.8 |
A=erythema; B=edema
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Propanediol-1,3 caused very slight or well-defined erythema of the treated skin and is, therefore, considered to be a slight primary skin irritant.
- Executive summary:
The test substance was tested on intact and abraded skin of rabbits in a semi-occlusive test for 24 hours. Propanediol-1,3 caused very slight or well-defined erythema of the treated skin and is, therefore, considered to be a slight primary skin irritant.
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