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EC number: 273-727-6 | CAS number: 69012-27-7 By-product of chromium refining containing oxides of aluminum, magnesium and silicon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Evaluation of an authoritative institution
Data source
Reference
- Reference Type:
- other: evaluation
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Evaluation of available data by authorative institution
- GLP compliance:
- no
Test material
- Reference substance name:
- Perlite
- EC Number:
- 603-442-8
- IUPAC Name:
- Perlite
- Reference substance name:
- 93763-70-3
- EC Number:
- 618-970-4
- Cas Number:
- 93763-70-3
- IUPAC Name:
- 93763-70-3
- Details on test material:
- Commercial perlite is a naturally occurring glass of volcanic origin, which, when heated, expands to form a product of low density, high surface area, and low thermal conductivity. The ore is essentially an amorphous, hydrated glassy volcanic rock consisting of fused sodium potassium aluminium silicate of variable composition. The chemical composition depends on the particular ore body in which it is found. The colour of crude perlite ranges from transparent light grey to glossy black. Perlite exists as crude and as expanded material.
Perlite ores and expanded perlite are about 75% non-crystalline silicate. Both may contain small amounts (<1% to 5.8%) of quartz.
Constituent 1
Constituent 2
Test animals
- Species:
- other: review of rat and mouse data
Administration / exposure
- Route of administration:
- oral: unspecified
- Details on oral exposure:
- Review of available data
- Doses:
- Review of available data
- No. of animals per sex per dose:
- Review of available data
- Details on study design:
- Review of available data
- Statistics:
- Review of available data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- > 10 000 mg/kg bw
Any other information on results incl. tables
The committee did not find data on the acute respiratory or dermal toxicity of perlite. The acute oral LD50 in mice was >12,960 mg/kg bw. No signs of toxicity were reported. In 2 other unpublished studies, the oral LD50 in rats was stated to be greater than 10,000 mg/kg bw, the highest dose tested.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The acute oral LD50 of perlite in rat and mouse is over 10000 mg/kg bw.
- Executive summary:
The committee did not find data on the acute respiratory or dermal toxicity of perlite. The acute oral LD50 in mice was >12,960 mg/kg bw. No signs of toxicity were reported. In 2 other unpublished studies, the oral LD50 in rats was stated to be greater than 10,000 mg/kg bw, the highest dose tested.
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