Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-979-3 | CAS number: 16921-30-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study apparently performed according to the method described in Federal Register 1973, Vol. 38, No. 187, Section 1500: 41, which has some significant deviations from current OECD guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Skin irritation patch test, as described in Federal Register 1973, Vol. 38, No. 187, Section 1500: 41.
- Deviations:
- not specified
- Principles of method if other than guideline:
- 0.5 g of material was applied on a gauze pad to abraded and non-abraded skin of six albino rabbits. The site was covered with adhesive tape. The sites were examined after 24 and 72 hours for erythema and oedema.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium hexachloroplatinate
- IUPAC Name:
- Sodium hexachloroplatinate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Sodium chloroplatinate
- Substance type: orange crystalline solid
- Physical state: solid
- Lot/batch No.: 031003
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: “recognised breeders”
- Age at study initiation: 14-16 weeks
- Weight at study initiation: 2.2 kg (average)
- Diet: ad libitum commercial rabbit diet from Rank Hovis MacDougal
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): “Natural lighting conditions”
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Backs of the rabbits were shaved (not “closely clipped” as recommended by the OECD guidelines). One site of each rabbit was abraded immediately before application of the test material, the other site remained intact.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 24 hrs
- Observation period:
- 48 hrs
- Number of animals:
- Six females
- Details on study design:
- TEST SITE
- Area of exposure: Each site 2.5 cm2 (one intact, one abraded)
- Type of wrap if used: Gauze pad was secured by “Sleek” tape (evidently a waterproof tape)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): None
SCORING SYSTEM: Erythema (and eschar) formation and oedema formation were assessed on the intact and abraded skin of six rabbits at 24 and 72 hrs after initial application of the test compound (i.e. as soon as the dressing was removed and again 48 hrs later). The primary irritation index was calculated by adding the four values for erythema (and eschar) formation to the four for oedema formation, and dividing the total by four. According to the study report, Draize (1959) considers that “compounds producing combined averages (primary irritation indices) of 2 or less are only mildly irritating; whereas those with indices of 2 to 5 are moderate irritants, and those with scores above 6 are considered severe irritants”.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hrs after initial application
- Score:
- 0.5
- Max. score:
- 8
- Reversibility:
- other: Reversibility not assessed, as observation period only 48 hrs (not up to 14 days as recommended in the OECD guidelines)
- Other effects:
- “Three abraded sites showed local areas of necrosis where the sample had entered abrasions on the epidermis. The systemic toxicity was not reported.
Any other information on results incl. tables
Table: Individual scores for each time point
Animal number | Time/hr | Erythema | Oedema | ||
Abraded skin | Intactskin | Abraded skin | Intact skin | ||
1 | 24 | 0 | 0 | 0 | 0 |
72 | 0 | 0 | 0 | 0 | |
2 | 24 | 1N | 0 | 0 | 0 |
72 | 2N | 0 | 1 | 0 | |
3 | 24 | 0 | 0 | 0 | 0 |
72 | 0 | 0 | 0 | 0 | |
4 | 24 | 0 | 0 | 0 | 0 |
72 | 1N | 0 | 1 | 0 | |
5 | 24 | 0 | 0 | 0 | 0 |
72 | 0 | 0 | 0 | 0 | |
6 | 24 | 1N | 0 | 1 | 0 |
72 | 2N | 0 | 2 | 0 |
N: Local areas of necrosis where the sample has entered abrasions on the epidermis
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an early US guideline study, sodium hexachloroplatinate (0.5 g) was applied (24-hr, occluded) to the shaved abraded and intact skin of six rabbits. No evidence of irritation to intact skin was observed during the observation period.
- Executive summary:
In a US Federal Register Patch Test (1973), the skin irritant potential of sodium hexachloroplatinate was assessed in six female New Zealand White rabbits. The test material (0.5 g) was applied (occluded) to the shaved abraded and intact skin for 24 hr.The sites were assessed for evidence of erythema (and eschar) formation and oedema formation immediately upon removal of the patch, and again 48 hr later.
The intact skin sites displayed no evidence of erythema/oedema at either time point. Three abraded sites showed evidence of possible necrosis associated with the abrasions in the skin.A Primary Irritation Score of 0.5 (out of 8) was obtained. The study authors classified sodium hexachloroplatinate as a mild skin irritant in this test system
This study suffered from a number of significant deviations from those given in the current OECD guidelines, including use of abraded skin, no moistening of test substance (a powder) to ensure good skin contact, a longer exposure period and failure to wash off any residual test material after removal of patch, observation period was insufficient to assess reversibility of effects, and skin was only examined on 2 occasions, at 0 and 48 hrs, rather than at 1, 24, 48 and 72 hrs, after patch removal. However, certain of these deviations are likely to increase the possibility of an irritant reaction.
Based on the results of this study, no classification for skin irritation is required under EUCLP criteria (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.