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EC number: 210-894-6 | CAS number: 625-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant study performed according to OECD Guideline 412.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- Methoxyacetic acid
- EC Number:
- 210-894-6
- EC Name:
- Methoxyacetic acid
- Cas Number:
- 625-45-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-methoxyacetic acid
- Reference substance name:
- 2-methoxyacetic acid
- IUPAC Name:
- 2-methoxyacetic acid
- Details on test material:
- - Name of test material: Methoxyacetic acid
- Analytical purity: 98.2 %
- Molecular weight: 90.09 g/mol
- Physical state: liquid
- Stability under test conditions: 6 months (room temperature)
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- 6 hours/day, 5 days per week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0 ppm
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
22.8 mg/m3 (= 6.1 ppm)
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
58.8 mg/m3 (= 15.7 ppm)
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
156.9 mg/m3 (= 42.0 ppm)
Basis:
analytical conc.
- No. of animals per sex per dose:
- 15 males (5 plus 10 for reproduction) and 5 females (plus 20 females for testing of reprotoxicity wihout exposition, mating 2:1)
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 60 mg/m³ air
- Sex:
- male/female
- Basis for effect level:
- other: Observed findings.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Species- and strain-specific changes as well as minor changes of clinical parameters were observed. With respect to males, in the high-dose group reduced weight of the thymus (significant) and testes (non-significant) were observed. In the case of females, in the high-dose group a (non-significant) reduced weight of the thymus was observed. Histologic pathology revealed substance-related changes in the testes. No other compound related effects were demonstrated by histopathology. Concerning reproductive effects, investigations on reproduction were inconclusive with respect to male fertility. A NOEL of 60 mg/m³ air was derived.
Applicant's summary and conclusion
- Executive summary:
In a subchronic inhalation toxicity study Methoxyacetic acid (98.2% a.i.) was administered to male and female Wistar rats (5/sex/concentration) by nose only exposure at concentrations of 0, 22.8, 58.8, 156.9 mg/m3 for 6 hours per day, 5 days/week for a total of 28 days. In addition, 10 male were exposed as satellite group per dose to investigate reproductive effects. In general, exposition was well-tolerated by animals. No animal died. Species- and strain-specific changes as well as minor changes of clinical parameters were observed. With respect to males, in the high-dose group reduced weight of the thymus (significant) and testes (non-significant) were observed. In the case of females, in the high-dose group a (non-significant) reduced weight of the thymus was observed. Histologic pathology revealed substance-related changes in the testes. No other compound related effects were demonstrated by histopathology. Concerning reproductive effects, investigations on reproduction were inconclusive with respect to male fertility. The NOAEL is 60 mg/m3based on the findings of the study. This subchronic toxicity study in the rat is acceptable and satisfies the guideline requirement (OECD 412) for a subchronic inhalation study in the rat.
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