Methoxyacetic acid

Specific investigations: other studies

Administrative data

Endpoint:

specific investigations: other studies

Type of information:

other: Physiologically based pharmacokinetic model

Adequacy of study:

other information

Study period:

1995

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Physiologically based pharmacokinetic models applicable to organogenesis: extrapolation between species and potential use in prenatal toxicity risk assessments

Author:

Welsch F, Blumenthal G M, Conolly R B

Year:

1995

Bibliographic source:

Toxicol. Lett., 82/83: 539-547.

Materials and methods

Principles of method if other than guideline:

Physiologically based pharmacokinetic modei (PBPK model)

Test material

Test material information

Constituent 1

Reference substance name:

Methoxyacetic acid

EC Number:

210-894-6

EC Name:

Methoxyacetic acid

Cas Number:

625-45-6

Molecular formula:

C3H6O3

IUPAC Name:

2-methoxyacetic acid

Constituent 2

Reference substance name:

2-methoxyacetic acid

IUPAC Name:

2-methoxyacetic acid

Applicant's summary and conclusion

Executive summary:

A physiologically based pharmacokinetic (PBPK) model describing the disposition of Methoxyacetic acid was developed in pregnant rodents. This model was validated with pharmacokinetic data from dams and embryos during major organogenesis. A physiological model of human pregnancy was then combined with the PBPK model and linked to an empirical Methoxyacetic acid pharmacokinetic model with two maternal compartments and a single or multiple conceptus compartment (depending on the developmental stage). This approach is intended to allow more realistic human pregnancy risk assessments.