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Diss Factsheets
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EC number: 271-816-4 | CAS number: 68609-04-1 The complex combination of hydrocarbons produced by the distillation of products from the air oxidation of cyclohexane after removal of acidic materials. It consists of hydrocarbons having carbon numbers predominantly in the range of C6 through C12 and boiling in the range of approximately 172°C to 324°C (342°F to 615°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- BASF-Test: The animals were shaved on their ventral side four days before test initiation. Then, the animals were placed for 4 hours in a tub filled with 10-15 g of the undiluted test substance in such a manner that their shaven bellies were exposed to the test compound. At the end of the exposure period, the animals were washed with concentrated lutrol and dried by means of tissue paper. The test animals were observed for clinical signs and lethality several times during the exposure period and then daily during the 6-11 days observation period. Animals that died during the course of the study were submitted to necropsy.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclohexane, oxidized, non-acidic by-products, distn. residues
- EC Number:
- 271-816-4
- EC Name:
- Cyclohexane, oxidized, non-acidic by-products, distn. residues
- Cas Number:
- 68609-04-1
- IUPAC Name:
- (1s,4s)-cyclohexane-1,4-diol (cyclohexyloxy)cyclohexane 2-butylcyclohexan-1-one 8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7)-diene cyclohexane cyclohexane-1,3-diol cyclohexanol phenol hydrate
- Details on test material:
- - Name of test material (as cited in study report): Anone destillation residue
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation: 110 g
Administration / exposure
- Type of coverage:
- other: exposed skin was submerged in test substance
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- 10 white rabbits were fixed with their stomach onto a special bowl containing 10-15g of the test solution. By doing so a 25-65 cm2 area of the shaved skin were exposed for 4h. The post-exposure observation period was 6-11 days.
- Duration of exposure:
- 4 h
- Doses:
- 10-15 g
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8-11 days
- Frequency of observations: The test animals were observed for clinical signs and lethality several times during the exposure period and then daily during the 8-11 days of observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
- Mortality:
- no mortalities were observed
- Clinical signs:
- Apathy was observed on the day of treatment. No symptoms were observed one day after exposure.
- Gross pathology:
- no abnormalities were detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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