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EC number: 271-816-4 | CAS number: 68609-04-1 The complex combination of hydrocarbons produced by the distillation of products from the air oxidation of cyclohexane after removal of acidic materials. It consists of hydrocarbons having carbon numbers predominantly in the range of C6 through C12 and boiling in the range of approximately 172°C to 324°C (342°F to 615°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
- Principles of method if other than guideline:
- BASF-Test: The substance was injected into the peritoneal cavity. Young adult laboratory mice were purchased from breeder. Usually the source and strain of animals were not documented. Several groups of 5 mice per sex and dose were treated simultaneously with preparations of the test substance in suitable vehicle. The concentrations of these preparations were used to achieve comparable volumes per kg body weight. Group-wise documentation of clinical signs was performed over the 7 day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexane, oxidized, non-acidic by-products, distn. residues
- EC Number:
- 271-816-4
- EC Name:
- Cyclohexane, oxidized, non-acidic by-products, distn. residues
- Cas Number:
- 68609-04-1
- IUPAC Name:
- (1s,4s)-cyclohexane-1,4-diol (cyclohexyloxy)cyclohexane 2-butylcyclohexan-1-one 8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7)-diene cyclohexane cyclohexane-1,3-diol cyclohexanol phenol hydrate
- Details on test material:
- - Name of test material (as cited in study report): Liquid Anon-destillation residue
- condensation products of cyclohexanol and cyclohexanon of unknown chemical structure. Ash-content approx. 2% (determined as sulfate-ash).
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation:
2000 mg/kg bw: male 20-26 g, female 20-23 g
1600 mg/kg bw: male 26-35 g, female 16-23 g
1250 mg/kg bw: male 26-32 g, female 22-26 g
1000 mg/kg bw: male 23-30 g, female 18-26 g
800 mg/kg bw: male 27-33 g, female 23-27 g
640 mg/kg bw: male 22-30 g, female 21-25 g
500 mg/kg bw: male 22-33 g, female 16-32 g
400 mg/kg bw: male 22-27 g, female 21-23 g
200 mg/kg bw: female 17-23 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: traganth
- Details on exposure:
- VEHICLE
- Concentration in vehicle (%): 2, 4, 8 and 20 - Doses:
- 2000, 1600, 1250, 1000, 800, 640, 500, 400 and 200 ml/kg bw (corresponding to 2103, 1682, 1314, 1052, 841, 673, 526, 421 and 210 mg/kg bw) Calculation based on the density of the test substance (1.0515 g/cm3 at 20 °C)
- No. of animals per sex per dose:
- 5 for 400-2000 ml/kg bw dose groups,
5 (only females) for 200 ml/kg bw dose group - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Frequency of observations and weighing: mortality and clinical signs of toxicity were observed several times on the application day and thereafter once each working day, body weights were only recorded at the beginning of the study.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 1 682 mg/kg bw
- Mortality:
- see free text
- Clinical signs:
- agitation, trembling, apathy later atony, lateral position, narcosis state
- Gross pathology:
- Deceased animals: skicky organs in the abdominal cavity.
Sacrificed animals: substance rests on the serosa of abdominal organs
Any other information on results incl. tables
Dose (ml/kg bw) |
Mortality in |
|||
24 h |
48 h |
7 days |
10 days |
|
2000 |
5/10 |
8/10 |
9/10 |
10/10 |
1600 |
1/10 |
3/10 |
4/10 |
4/10 |
1250 |
0/10 |
0/10 |
3/10 |
3/10 |
1000 |
0/10 |
0/10 |
0/10 |
0/10 |
800 |
0/10 |
0/10 |
1/10 |
1/10 |
640 |
0/10 |
0/10 |
0/10 |
0/10 |
500 |
0/10 |
0/10 |
0/10 |
0/10 |
400 |
0/10 |
0/10 |
0/10 |
0/10 |
200 |
0/5 |
0/5 |
0/5 |
0/5 |
LD50 = 1600 ml/kg bw (corresponding to 1682 mg/kg bw)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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