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Diss Factsheets
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EC number: 206-992-3 | CAS number: 420-04-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Report deficiencies: E.g. temperature of air, humidity of air, equipment for measuring temperature, humidity and particulate aerosol. No data of body weight, individual clinical signs and gross pathological findings.
- Principles of method if other than guideline:
- Some minor report deficiencies which are considered to have no impact on the quality of the results:
e.g. temperature of air, humidity of air, equipment for measuring temperature, humidity and particulate aerosol. No data of body weight, individual clinical signs and gross pathological findings. - GLP compliance:
- no
- Remarks:
- The study was conducted prior to implementation of GLP.
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Cyanamide
- EC Number:
- 206-992-3
- EC Name:
- Cyanamide
- Cas Number:
- 420-04-2
- Molecular formula:
- CH2N2
- IUPAC Name:
- cyanamide
- Test material form:
- other: aqueous solution
- Details on test material:
- - Name of test material (as cited in study report): Cyanamid L500
- Appearance: Clear yellowish liquid
- Analytical purity: 53 % (w/v)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Central Institute for the Breeding of Laboratory Animals TNO, Zeist, Netherlands
- Body weight at the study initiation was about 200 g for males and about 180 g for females
Administration / exposure
- Route of administration:
- other: Inhalation: mists
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 2.0 mg/ L of technical active Cyanamid L500
- No. of animals per sex per dose:
- 5 animals per sex per dose (one dose)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: Corresponding to technical active Cyanamid L500 > 2.0 mg/L.
- Mortality:
- No mortalities were recorded during the study.
- Clinical signs:
- other: During the exposure a lumback behaviour and a rapid shallow respiration with frequent coughing and swallowing were observed. Within a few hours after exposure all animals were completely recovered and showed normal behaviour.
- Body weight:
- Not indicated
- Gross pathology:
- No visible lesions were observed at gross necropsy.
- Other findings:
- No other findings
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The inhalative LC50 of cyanamide was > 1 mg/L in male and female rats after 4 hour inhalation (corresponding to technical active Cyanamid L500 > 2.0 mg/L).
- Executive summary:
The toxicity of Cyanamid L500 (a 50 % aqueous solution) by the inhalation route (whole-body) was investigated in five male and five female Wistar rats. The rats were exposed to the mist of technical active cyanamide in a concentration of 2.0 mg/L of air (corresponding to the highest technical attainable concentration) for four hours.
No mortalities were recorded during the study. During the exposure a lumback behaviour and a rapid shallow respiration with frequent coughing and swallowing were observed. Within a few hours after exposure all animals were completely recovered and showed normal behaviour. No visible lesions were observed at gross necropsy.
The inhalative LC50 of cyanamide was > 1 mg/L in male and female rats after 4 hour inhalation (corresponding to technical active Cyanamid L500 > 2.0 mg/L).
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