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EC number: 911-254-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The test is conducted based on OECD-GLP standard and OECD test guideline. No data on analytical monitoring. The results are taken into account for the weight of evidence analysis.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Test organisms (species):
- no data
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.5 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 96 h-LC50: 2.5 mg/L
- Executive summary:
Short-term toxicity of 6-tert-butyl-2,4-xylenol was studied in fish, according to OECD guideline 203. The result for 96 h-LC50 was 2.5 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tertbutyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.5 mg/L
- Remarks on result:
- other: read-across from an analogue for which LC50 (96 h) = 2.5 mg/L
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue substance 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 2.5 mg/L.
- Executive summary:
The 96h-LC50 of 6-tert-butyl-2,4-xylenol is 2.5 mg/L (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, - March 2009). Based on this result, the read-across approach was applied and the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 2.5 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tertbutyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.4 mg/L
- Remarks on result:
- other: read-across from an analogue for which LC50 (96 h) = 4.4 mg/L
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue substance 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 4.4 mg/L.
- Executive summary:
The 96h-LC50 of 6-tert-butyl-2,4-xylenol is 4.4 mg/L (Results of Eco-toxicity tests of chemicals conducted by Environment Agency in Japan). Based on this result,the read-across approach was applied and the96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 4.4 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- OECD guideline. No GLP study. Analytical monitoring was not conducted. The results are taken into account for the weight of evidence analysis.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- Stock solution was prepared with DMSO:HCO-40= 4:1(99-990 mg/l).
- Test organisms (species):
- Oryzias latipes
- Test type:
- semi-static
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Nominal and measured concentrations:
- 5 nominal concentrations (1.0-10 mg/l)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: (95% confidence limits:3.2-9.3 mg/l)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 96 h-LC50: 4.4 mg/L
- Executive summary:
Short-term toxicity of 6-tert-butyl-2,4-xylenol was studied in fish, according to OECD guideline 203. The result for 96 h-LC50 was 4.4 mg/L.
Referenceopen allclose all
Description of key information
Weight of evidence: Read-across from published experimental data on the substance 6-tert-Butyl-2,4-xylenol.
Test according to OECD guideline 203 and GLP study. 96-h LC50 = 2.5 mg/l
Test according to OECD guideline 203. No GLP study. 96-h LC50 = 4.4 mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.5 mg/L
Additional information
Weight of evidence: Read-across from published experimental data on the substance 6-tert-Butyl-2,4-xylenol.
Test according to OECD guideline 203 and GLP study. 96-h LC50 = 2.5 mg/l
Test according to OECD guideline 203. No GLP study. 96-h LC50 = 4.4 mg/l
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
Based on published experimental data on the analogue 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the read-across approach is applied.
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