Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 911-254-5 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The test is conducted based on OECD-GLP standard and OECD test guideline. No data on analytical monitoring. The results are taken into account for the weight of evidence analysis.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Test organisms (species):
- no data
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.5 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 96 h-LC50: 2.5 mg/L
- Executive summary:
Short-term toxicity of 6-tert-butyl-2,4-xylenol was studied in fish, according to OECD guideline 203. The result for 96 h-LC50 was 2.5 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tertbutyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.5 mg/L
- Remarks on result:
- other: read-across from an analogue for which LC50 (96 h) = 2.5 mg/L
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue substance 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 2.5 mg/L.
- Executive summary:
The 96h-LC50 of 6-tert-butyl-2,4-xylenol is 2.5 mg/L (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, - March 2009). Based on this result, the read-across approach was applied and the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 2.5 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tertbutyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.4 mg/L
- Remarks on result:
- other: read-across from an analogue for which LC50 (96 h) = 4.4 mg/L
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue substance 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 4.4 mg/L.
- Executive summary:
The 96h-LC50 of 6-tert-butyl-2,4-xylenol is 4.4 mg/L (Results of Eco-toxicity tests of chemicals conducted by Environment Agency in Japan). Based on this result,the read-across approach was applied and the96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 4.4 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- OECD guideline. No GLP study. Analytical monitoring was not conducted. The results are taken into account for the weight of evidence analysis.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- Stock solution was prepared with DMSO:HCO-40= 4:1(99-990 mg/l).
- Test organisms (species):
- Oryzias latipes
- Test type:
- semi-static
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Nominal and measured concentrations:
- 5 nominal concentrations (1.0-10 mg/l)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: (95% confidence limits:3.2-9.3 mg/l)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 96 h-LC50: 4.4 mg/L
- Executive summary:
Short-term toxicity of 6-tert-butyl-2,4-xylenol was studied in fish, according to OECD guideline 203. The result for 96 h-LC50 was 4.4 mg/L.
Referenceopen allclose all
Description of key information
Weight of evidence: Read-across from published experimental data on the substance 6-tert-Butyl-2,4-xylenol.
Test according to OECD guideline 203 and GLP study. 96-h LC50 = 2.5 mg/l
Test according to OECD guideline 203. No GLP study. 96-h LC50 = 4.4 mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.5 mg/L
Additional information
Weight of evidence: Read-across from published experimental data on the substance 6-tert-Butyl-2,4-xylenol.
Test according to OECD guideline 203 and GLP study. 96-h LC50 = 2.5 mg/l
Test according to OECD guideline 203. No GLP study. 96-h LC50 = 4.4 mg/l
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
Based on published experimental data on the analogue 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the read-across approach is applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
