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Ecotoxicological information

Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
The test is conducted based on OECD-GLP standard and OECD test guideline. No data on analytical monitoring. The results are taken into account for the weight of evidence analysis.
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes
Analytical monitoring:
not specified
Test organisms (species):
no data
Test type:
not specified
Water media type:
not specified
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2.5 mg/L
Validity criteria fulfilled:
not specified
Conclusions:
96 h-LC50: 2.5 mg/L
Executive summary:

Short-term toxicity of 6-tert-butyl-2,4-xylenol was studied in fish, according to OECD guideline 203. The result for 96 h-LC50 was 2.5 mg/L.

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tertbutyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
See attached the reporting format.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2.5 mg/L
Remarks on result:
other: read-across from an analogue for which LC50 (96 h) = 2.5 mg/L
Validity criteria fulfilled:
not applicable
Conclusions:
Based on read-across approach from experimental data on analogue substance 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 2.5 mg/L.

Executive summary:

The 96h-LC50 of 6-tert-butyl-2,4-xylenol is 2.5 mg/L (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, - March 2009). Based on this result, the read-across approach was applied and the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 2.5 mg/L.

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tertbutyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.
See attached the reporting format.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4.4 mg/L
Remarks on result:
other: read-across from an analogue for which LC50 (96 h) = 4.4 mg/L
Validity criteria fulfilled:
not applicable
Conclusions:
Based on read-across approach from experimental data on analogue substance 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the 96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 4.4 mg/L.

Executive summary:

The 96h-LC50 of 6-tert-butyl-2,4-xylenol is 4.4 mg/L (Results of Eco-toxicity tests of chemicals conducted by Environment Agency in Japan). Based on this result,the read-across approach was applied and the96 h-LC50 of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol is determined to be 4.4 mg/L.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
OECD guideline. No GLP study. Analytical monitoring was not conducted. The results are taken into account for the weight of evidence analysis.
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
yes
Details on test solutions:
Stock solution was prepared with DMSO:HCO-40= 4:1(99-990 mg/l).
Test organisms (species):
Oryzias latipes
Test type:
semi-static
Water media type:
not specified
Total exposure duration:
96 h
Nominal and measured concentrations:
5 nominal concentrations (1.0-10 mg/l)
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4.4 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: (95% confidence limits:3.2-9.3 mg/l)
Validity criteria fulfilled:
not specified
Conclusions:
96 h-LC50: 4.4 mg/L
Executive summary:

Short-term toxicity of 6-tert-butyl-2,4-xylenol was studied in fish, according to OECD guideline 203. The result for 96 h-LC50 was 4.4 mg/L.

Description of key information

Weight of evidence: Read-across from published experimental data on the substance 6-tert-Butyl-2,4-xylenol.

Test according to OECD guideline 203 and GLP study. 96-h LC50 = 2.5 mg/l

Test according to OECD guideline 203. No GLP study. 96-h LC50 = 4.4 mg/l

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
2.5 mg/L

Additional information

Weight of evidence: Read-across from published experimental data on the substance 6-tert-Butyl-2,4-xylenol.

Test according to OECD guideline 203 and GLP study. 96-h LC50 = 2.5 mg/l

Test according to OECD guideline 203. No GLP study. 96-h LC50 = 4.4 mg/l

The substance CAS No. 1879-09-0 is one of the main components of the reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol and it is present in a concentration of more than 70%. Therefore, the results obtained with the substance CAS No. 1879-09-0 can be used for the read-across approach.

 

Based on published experimental data on the analogue 6-tert-butyl-2,4-xylenol (CAS 1879-09-0), the read-across approach is applied.