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EC number: 425-050-4 | CAS number: 10217-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate national standard method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation: Human and Domestic Aminals, Section 81-1. And: TSCA Health Effects Test Gudelines, 40 CFR 798.1175.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 425-050-4
- EC Name:
- -
- Cas Number:
- 10217-34-2
- Molecular formula:
- C14H28O4Si
- IUPAC Name:
- triethoxy(2-{7-oxabicyclo[4.1.0]heptan-3-yl}ethyl)silane
- Details on test material:
- Test article ID (as cited in the study): Y-4036 is beta-(3,4-epoxycyclohexyl)ethyltriethoxysilane
Molecular formula: C13H26O4Si
Molecular weight: 274,43
Physical state: Clear, colorless liquid
Analytical purity: 98.3%
Lot/batch no: 16912-29
Source: OSi Specialities, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591
Test article receipt: 1995-09-18 (expiration date was not provided)
Stability under test conditions: Stable
Storage condition of test material: At room temperature; protected from exposure to light
Certificate of analysis: see appendix IV (GC, FTIR, GC/MS)
Constituent 1
Test animals
- Species:
- other: Albino rat
- Strain:
- other: Crl:CD BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc. Kingston, NY
- Age at study initiation: young adult
- Weight at study initiation: 236 to 251 grams at initiation of dosing
- Housing: Individual suspended wire-mesh cages. The animals were maintained by the animal husbandry staff of WIL Research Laboratories, Inc., in accordance with Standard Operating Procedures
- Fasting period: The rats were fasted approximately 18 to 20 hours prior to dosing and returned to feed 3 to 4 hours after dosing
- Diet (e.g. ad libitum): Purina Certified Rodent Chow #5002, ad libitum
- Water (e.g. ad libitum): municipal water, ad libitum.
- Acclimation period: The animals were acclimated to laboratory conditions for a minimum of seven days prior to initiation of dosing.
ENVIRONMENTAL CONDITIONS
- Temperature: 71.8-72.1 °F
- Humidity: 21-47.1 %
- Photoperiod (12 hrs dark /12 hrs light):
IN-LIFE DATES: From: To: no details given
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation: on initiation day 1, 3 and 4 hours after dose and then daily for 14 days; weighing on study days -1, 0 (initiation), 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, mortality, necrosy
Results and discussion
- Preliminary study:
- A range finding study was conducted in which groups of one male and one female rat were dosed at levels of 500, 1000, 2000, 3500 and 5000 mg/kg. There were no deaths during the range-finding study. Based on these results, 5000 mg/kg was selected as the first level on the main study.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: All clinical findings were noted within three days of dosing. Dried red material around the eye(s), nose and/or mouth was observed for seven animals. Six rats had wet and/or dried yellow urogenital and/or ventral
- Gross pathology:
- Effects on organs:
No treatment related findings.
Any other information on results incl. tables
Mean body weights (days -1/0/7/14) (g) | Clinical Observations | |||
Dose (mg/kg bw) | Male | Female | Male | Female |
5000 | 269/243/308/349 | 264/239/286/298 | dried red material around the eye(s), nose and/or mouth; 2 animals | dried red material around the eye(s), nose and/or mouth; 5 animals |
dried yellow urogenital staining; 2 animals | wet and/or dried yellow urogenital and/or ventral abdominal staining; 4 animals | |||
Hypoactive; 1 animal | Hypoactive 4 animals |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A reliable study conducted according a appropriate guideline, identified a LD50 range of > 5000 mg/kg bw in female and male rats, respectively. No treatment related findings were noted up to the highest dose tested.
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