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EC number: 469-070-1 | CAS number: 17861-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 Oct 2016 - 17 Oct 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 24 February 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 469-070-1
- EC Name:
- -
- Cas Number:
- 17861-60-8
- Molecular formula:
- C9H26O2Si3
- IUPAC Name:
- 4-ethyl-2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptane
- Test material form:
- liquid
- Remarks:
- Clear colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- RccHAN (TM); WIST
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 8 to 12 weeks
- Weight at study initiation: at least 200g, weight variation did not exceed +/- 20% of the mean weight for each sex
- Housing: individually during 24h exposure period, in groups of 5, by sex, for the remainder of the study
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19 - 25°C
- Humidity: 30 - 70%
- Air changes (per hr): 15
- Photoperiod (dark / hrs light): 12h/12h
IN-LIFE DATES: From: 03 Oct 2016 To: 17 Oct 2016
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks
- % coverage: approx. 10%
REMOVAL OF TEST SUBSTANCE
- Washing (if done): treated skin and surrounding hair wiped with cotton wool moistened with distilled water
- Time after start of exposure: 24h
TEST MATERIAL
- Amount applied: 2.44mL/kg bw - Duration of exposure:
- 24h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
Frequency of observations and weighing observation after dosing: 30min, 1, 2, 3 and 4 h and subsequently daily for 14 days, body weights recorded on days 0, 7 and 14
Evaluation of skin reactions: after removal of dressing and subsequently once daily for 14 days
- Necropsy of survivors performed: yes - Statistics:
- Not performed
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- no mortality observed
- Clinical signs:
- other: no signs of systemic toxicity observed
- Gross pathology:
- no abnormalities were noted at necropsy
Any other information on results incl. tables
table1: results male
male animal nr |
observation time | ||
1-7d | 8-14d | ||
1-0 | erythema | 0 | 0 |
edema | 0 | 0 | |
1-1 | erythema | 0 | 0 |
edema | 0 | 0 | |
1-2 | erythema | 0 | 0 |
edema | 0 | 0 | |
1-3 | erythema | 0 | 0 |
edema | 0 | 0 | |
1-4 | erythema | 0 | 0 |
edema | 0 | 0 |
table 2: results female
female animal nr |
observation time | ||
1-7d | 8-14d | ||
2-0 | erythema | 0 | 0 |
edema | 0 | 0 | |
2-1 | erythema | 0 | 0 |
edema | 0 | 0 | |
2-2 | erythema | 0 | 0 |
edema | 0 | 0 | |
2-3 | erythema | 0 | 0 |
edema | 0 | 0 | |
2-4 | erythema | 0 | 0 |
edema | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal median lethal dose (LD50) of the test item in the Wistar strain rat was found to be greater than 2000 mg/kg bw.
The test item does not meet the criteria for classification according to the Globally Harminized System of Classification and labelling of Chemicals. - Executive summary:
The acute dermal toxicity of heptamethylethyltrisiloxane was investigated in male and female RccHan:WIST rats at a dose level of 2000 mg/kg bw (24 hour exposure) followed by a 14 day observation period. There were no deaths at 2000 mg/kg bw. There were no treatment related clinical signs, nor effects on bodyweight gain with the exception of 2 females during the first week of observation. Histopathological examination revealed no effects of the test substance.
The acute dermal median lethal dose (LD50) of heptamethylethyltrisiloxane in rats was found to be greater than 2000 mg/kg bw
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