Registration Dossier
Registration Dossier
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EC number: 615-275-8 | CAS number: 71301-98-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA-Guideline, Federal Register, Vol. 42, No. 103, §163.81-4, p. 37359f "primary eye irritation study"
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl 2-(4-hydroxyphenoxy)propionate
- EC Number:
- 265-704-4
- EC Name:
- Ethyl 2-(4-hydroxyphenoxy)propionate
- Cas Number:
- 65343-67-1
- IUPAC Name:
- ethyl 2-(4-hydroxyphenoxy)propanoate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand
Test system
- Vehicle:
- other: Polyethylenglycol 400
- Controls:
- no
- Duration of treatment / exposure:
- 24h
- Observation period (in vivo):
- 7d
- Number of animals or in vitro replicates:
- 9
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0.88
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0.55
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 1.5
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0.83
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7d
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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