Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-156-1 | CAS number: 927-62-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
- Principles of method if other than guideline:
- Screening tests, like ear swelling test etc.
- GLP compliance:
- not specified
- Type of study:
- mouse ear swelling test
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- several other primary aliphatic amines
Constituent 1
Results and discussion
Any other information on results incl. tables
There are no experimental results for N,N-dimethylbutylamine itself known to exist. However, structurally related primary alkylaminese.g. cyclohexylamine, hexylamine, n-octylamine, isopropylamine, 2-aminobutane) failed to produce an allergic response in screening test (e.g. mouse-ear swelling test).
Hence, N,N-dimethylbutylamine is not supposed to raise concern over a skin sensitising activity.
Applicant's summary and conclusion
- Executive summary:
There are no experimental results for N,N-dimethylbutylamine itself.
Structure-related primary alkylamines (e.g. cyclohexylamine, hexylamine, n-octylamine, isopropylamine, 2-aminobutane) failed to produce an allergic response in screening test (e.g. mouse-ear swelling test).
Hence, 3-methylbutylamine is not supposed to raise concern over a skin sensitising activity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
