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EC number: 202-874-0 | CAS number: 100-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
In a valid study performed according to international ISO guideline 9439 close to OECD 301B (reliability category 2) the test item cyclohexanone oxime was assessed to be readily biodegradable meeting the 10-day window requirement.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
In a valid study performed according to international ISO guideline 9439 close to OECD 301B (reliability category 2) the test item cyclohexanone oxime was assessed to be readily biodegradable meeting the 10-day window requirement. An initial test item concentration of nominal 63 mg/L was applied, corresponding to 40 mg/L DOC/TOC. Non-adapted activated sludge from laboratory sewage treatment plant receiving sewage of domestic and synthetic origin was used in a final solids concentration of 5 mg/L. Validity criteria of the guidelines were fulfilled. Based on CO2 evolution, within 28 days a mean degradation (2 replicates) of 79% was reached. Elimination deduced from DOC reduction amounted to 100% within 28 days.
This result is supported by a test on inherent biodegradability (Zahn-Wellens test) performed according to EU method C.9 (equivalent to OECD 302B; reliability category 2). An initial test item concentration of nominal 656 mg/L was applied, corresponding to 400 mg/L DOC (nominal). Non-adapted sludge from a STP receiving industrial and domestic sewage was applied with a final concentration of solids of 0.5 g/L.
Adsorption (3 -hours value) was determined to be negligible (2.7%). Adaption phase was very short, as already between day 1 and 3 degradation phase began and at day 3 already 50.2% of the test item were degraded. The final degradation level at the end of the test amounted to 96.5%. Reported degradation is exclusive of elimination, i.e. the DOC determined after 3 hours was taken as the reference value according to the EU-guideline.
Conclusions:
- Cyclohexanone oxime is inherently biodegradable, fulfilling specific criteria (≥70 % mineralisation (DOC removal) within 7 d; log phase no longer than 3d; removal before degradation occurs was below 15%, namely 2.7% and inoculum was not pre-adapted).
- Elimination due to adsorption was negligible (2.7% within 3 hours).
- Inoculum toxicity can safely be excluded at the initial nominal concentration of cyclohexanone oxime of 656 mg/L.
The Zahn-Wellens test will be used as key study for hazard assessment for STP microorganisms. In line with REACH guidance on Information Requirements and Chemical Safety Assessment part R.10 the initial nominal concentration of cyclohexanone oxime of 656 mg/L will be regarded as a NOEC STP-microorganisms.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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