Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-221-0 | CAS number: 3033-77-0
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- other: EU Risk Assessment report
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Although the EU risk assessment report is secondary literature, all data and risk assessment for the human, health and the environment have been evaluated and reviewed by Finland prior to publication. The risk assessment report has been submitted to final approval and published in the Official Journal of the European Union C157/10 dated on 21.06.2008. Thus, it is considered the information reported is reliable with the restrictions that reliability of the data presented has not been assessed again.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- European Union Risk Assessment 2,3-epoxypropyltrimethylammonium chloride CAS RN 3033-77-0 Einecs No: 221-221-0
- Author:
- EC
- Year:
- 2 008
- Bibliographic source:
- Risk Assessment. Final approved version. Rapporteur: Finland (FIN). European communities. Printed in Italy. 147pp
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- BCFs were calculated according to EUSES
Test material
- Reference substance name:
- 2,3-epoxypropyltrimethylammonium chloride
- EC Number:
- 221-221-0
- EC Name:
- 2,3-epoxypropyltrimethylammonium chloride
- Cas Number:
- 3033-77-0
- Molecular formula:
- C6H14NO.Cl
- IUPAC Name:
- N,N,N-trimethyl(oxiran-2-yl)methanaminium chloride
- Details on test material:
- not applicable
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable
Sampling and analysis
- Details on sampling:
- not applicable
Test solutions
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable
Test organisms
- Details on test organisms:
- not applicable
Test conditions
- Hardness:
- not applicable
- Test temperature:
- not applicable
- pH:
- not applicable
- Dissolved oxygen:
- not applicable
- TOC:
- not applicable
- Salinity:
- not applicable
- Details on test conditions:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Details on estimation of bioconcentration:
- not applicable
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- ca. 1.41 L/kg
- Calculation basis:
- other: EUSES
- Remarks on result:
- other: in fish
- Type:
- BCF
- Value:
- ca. 3.34 L/kg
- Calculation basis:
- other: EUSES
- Remarks on result:
- other: in worm
- Details on kinetic parameters:
- not applicable
- Metabolites:
- not applicable
- Results with reference substance (positive control):
- not applicable
- Details on results:
- not applicable
- Reported statistics:
- not applicable
Any other information on results incl. tables
not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- BCFs calculated according to EUSES are: BCFFish =1.41 l/kg and BCFWorm = 3.34 kg/kg. Based on calculated BCFs no significant bioaccumulation is expected.
- Executive summary:
No experimental test result on bioaccumulation of EPTAC is available. Bioconcentration factors (BCF) for fish and earthworm can in principle be estimated according to TGD from certain relationship using known Kow. However, the equation in the TGD is relevant only for substances with a log Kow 1 – 6 (for EPTAC log Kow < -1.3). In addition for certain types of chemicals e.g. those which ionise in water, log Kow values may not be suitable for calculation of a BCF value. Therefore precaution should be taken to interpret the results from the calculations. BCFs calculated according to EUSES are: BCFFish =1.41 l/kg and BCFWorm = 3.34 kg/kg. Based on calculated BCFs no significant bioaccumulation is expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
