Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

November 1980 - March 1981

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This was an investigative study, not corresponding to any specific guidelines. This study was carried out prior to the implementation of Good Laboratory Practice (GLP) and, therefore, no claim is made as to its GLP compliance.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Objective of study:

absorption

distribution

metabolism

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

This was an investigative study, not corresponding to any specific guidelines.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

EC Number:

932-389-6

Molecular formula:

C23H19ClF3NO3

IUPAC Name:

Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

Radiolabelling:

yes

Test animals

Species:

rat

Applicant's summary and conclusion

Conclusions:

The study is considered to be reliable with restrictions.

Executive summary:

After oral administration of the test material to rats at 1 and 25 mg/kg, absorption was variable and accounted for about 55% of the dose. However, the proportions absorbed were similar at both dose levels. The test material absorbed after oral administration was completely metabolised and excreted as conjugated metabolites in urine and bile. Excretion was rapid for both¹⁴C-labelled forms in both sexes, and the metabolite patterns derived from each labelled form were completely different. Most of the radioactive dose was rapidly eliminated in the first 24 hours after dosing, but a small proportion of an oral dose (2 – 3%) was still retained in the animals after seven days. Tissue residue measurements showed that this material was probably located almost entirely in fat. These data support the choice of oral route for the toxicological testing of the test material in the rat.