Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 406-040-9 | CAS number: 125643-61-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study undertaken to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 406-040-9
- EC Name:
- -
- Cas Number:
- 125643-61-0
- Molecular formula:
- C24 H40 O3 C25 H42 O3 C26 H44 O3
- IUPAC Name:
- C7-9-(branched)-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1ml
- Concentration (if solution):
VEHICLE
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0.33
- Reversibility:
- fully reversible within: 3 days.
- Remarks on result:
- other: No other data
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0.66
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: No other data
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0.66
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: No other data
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: Overall at 24, 48 and 72h.
- Score:
- 0
- Remarks on result:
- other: No other data.
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0
- Remarks on result:
- other: No other data.
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: Overall at 24, 48 and 72h.
- Score:
- 0
- Remarks on result:
- other: No other data.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: Overall at 24, 48 and 72h.
- Score:
- 0
- Remarks on result:
- other: No other data.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: Overall at 24, 48 and 72h.
- Score:
- 0
- Remarks on result:
- other: No other data.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: Overall at 24, 48 and 72 h.
- Score:
- 0
- Remarks on result:
- other: No other data.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: Overall at 24. 48 and 72h.
- Score:
- 0
- Remarks on result:
- other: No other data.
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: Overall at 24, 48 and 72h.
- Score:
- 0
- Remarks on result:
- other: No other data.
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: Overall at 24, 48 and 72h.
- Score:
- 0
- Remarks on result:
- other: No other data.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
