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EC number: 935-721-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012, Nov 13 - 2012, Dec 13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (1-phenylethyl)-phenyloxymethyloxirane
- IUPAC Name:
- (1-phenylethyl)-phenyloxymethyloxirane
- Test material form:
- other: yellow liquid
- Details on test material:
- - Name of test material (as cited in study report): Novares LR 600, (1-phenylethyl)-phenyloxymethyloxirane
- Molecular formula (if other than submission substance):
- Molecular weight (if other than submission substance): mixture
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state:
- Analytical purity:
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.:
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions: The recoveries after 48 hours ranged from 107 % to 121 % of the start concentrations;
therefore the test item was stated as stable under the test conditions
- Storage condition of test material: Room temperature: (20 ± 5 °C); keep away from light and humidity
- Other:
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Nominal concentration < 5 mg/L in aqueous media: 100 mL of the solution in medium was extracted with 2 mL iso-octane, and the upper phase
was measured via GC/FID. 50-fold enrichment was achieved.
- Nominal concentration ≥ 5 mg/L but < 80 mg/L in aqueous media: 20 mL of the solution in medium was extracted with 2 mL iso-octane and the
upper phase was measured via GC/FID. Tenfold enrichment was achieved.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
As the solubility is ≤10 mg/L, water-accommodated fractions were prepared for the test. This was done by weighing of the nominal loads, adding the
corresponding amount of dilution water and shaking vigorously for 24 ± 1 hours in closed flasks.
The resulting solutions were filtrated through 0.45 µm filters.
Due to technical reasons, the weighed amounts of the test item for preparation of the water-accommodated fractions were differing by up to
13 % from the nominal amount. As the biological results were based on the measured concentrations, this was stated as uncritical.
Controls: Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) as positive control
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water Flea
- Strain: Berlin
- Source: LAUS GmbH, Germany (Origin: Umweltbundesamt Berlin)
- Age at study initiation (mean and range, SD): < 24 hrs; 19 hrs before the start of the test, the adult animals were separated from the young.
18 hrs later, the adults were caught with the help of a glass tube, and the newborn daphnia, aged between 0 and 18 hrs, were sieved from the
medium and placed into a 250 mL-beaker containing dilution water. After a settling-in period of 30 minutes, animals which showed no apparent
damage were used for the test.
- Method of breeding: no data
- Food type: unicellular green algae (Desmodesmus subspicatus)
- Feeding during test: none
- Medium: M4-Medium (recipe of ELENDT)
- Medium renewal: twice a week
- Photo period: 16/8 hrs, using neon tubes (lighting during test: none)
- Temperature 20 ± 2 °C (during test: 17.3 – 19.8 °C)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48
- Post exposure observation period:
- no data
Test conditions
- Hardness:
- 2.502 mmol/L; 250 mg CaCO3/L
- Test temperature:
- 20 ± 2 °C
- pH:
- 7.8 ± 0.2
- Dissolved oxygen:
- 8.1 mg/L throughtout the test
- Salinity:
- no data
- Nominal and measured concentrations:
- Nominal: 0.46 / 1.00 / 2.20 / 4.60 / 10.0 mg/L (loadings)
Measured: 0.34/ 1.07/ 1.78/ 3.32/ 5.25 mg/L at start of the test - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beakers, nominal volume: 100 ml (containing
- Type: closed
- Aeration: Yes
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4 (each containing 65 ± 5 mL test solution)
- No. of vessels per control (replicates): 4 (each containing 65 ± 5 mL solution of control substance)
- No. of vessels per vehicle control (replicates): 4 (each containing 65 ± 5 mL dilution water intstead of test solution)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionised water
OTHER TEST CONDITIONS
- Adjustment of pH: 7.8 ± 0.2
- Photoperiod: none
EFFECT PARAMETERS MEASURED: Mobility (immobilized and dead animals were counted at 24 h and 48 h of exposure)
TEST CONCENTRATIONS
- Test concentrations: nominal 0.46 / 1.0 / 2.2 / 4.6 / 10 mg/L (loadings) - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50/LC50: The 24h-EC50 of Potassium dichromate was determined as 1.5 mg/L, lying within the demanded range of 0.6 – 1.7 mg/L. - Reported statistics and error estimates:
- The determination of the biological results was based on the geometric mean of the measured concentration.
The geometric mean is calculated by multiplication of the n participating concentrations and extracting the nth root of the product.
Any other information on results incl. tables
The measured concentrations at the start of the test decreased with the loadings increasing and ranged between 52.5 % and 107 % of the nominal concentrations. Therefore, the determination of the biological results was based on the geometric mean of the measured concentration.
Table 8.1‑d (excerpted from original report) Measured Concentrations
Nominal Concentration in mg/L |
Measured Concentration in mg/L |
% Recovery after 48 h |
% of Nominal Concentration |
Geometric Mean in mg/L |
||
0 h |
48 h |
|
0 h |
48 h |
||
BW |
< LOQ |
< LOQ |
- |
- |
- |
- |
0.46 |
0.34 |
0.41 |
120.90 |
72.83 |
88.04 |
0.37 |
1 |
1.07 |
1.21 |
112.62 |
107.00 |
120.50 |
1.14 |
2.2 |
1.78 |
1.91 |
107.30 |
80.91 |
86.82 |
1.84 |
4.6 |
3.32 |
3.64 |
109.80 |
72.07 |
79.13 |
3.47 |
10 |
5.25 |
6.02 |
114.57 |
52.50 |
60.15 |
5.62 |
LOQ = Limit of quantification (0.1 mg/L)
Table 8.1‑a (excerpted from original report) Immobilities
Nominal Concentration in mg/L |
Immobility 24 hours |
Immobility 48 hours |
||||||||
abs. |
in % |
abs. |
in % |
|||||||
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.46 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1.0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2.2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
5 |
4.6 |
0 |
0 |
0 |
0 |
0 |
5 |
5 |
4 |
3 |
85 |
10 |
4 |
3 |
4 |
4 |
75 |
5 |
5 |
5 |
5 |
100 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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