Registration Dossier
Registration Dossier
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EC number: 620-056-5 | CAS number: 874195-61-6
Endpoint summary
Administrative data
Description of key information
The chemical safety assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to investigate further toxicity testing with terrestrial organisms.
Additional information
Terrestrial tests with triafamone are available for short-term toxicity to soil macroorgansims (earthworm Eisenia fetida), toxicity to terrestrial arthropods (honey bee Apis mellifera) and soil organisms (nitrogen and carbon transformation). The earthworm Eisenia fetida shows no mortality and no morphological and behavioural effects during the 14 days test duration. The study according to OECD guideline 207 and GLP resulted in a LC50 (14d) of > 1000 mg/kg soil dw. In both tests with honey bees (acute contact and acute oral), no significant mortality occurred in the water and solvent controls and no behavioural or other biological effects were observed. Therefore, the LD50 (48 h) for contact toxicity was > 100 µg a.i./bee and the LD50 (48 h) for oral toxicity was > 55.8 µg a.i./bee. The test with soil microorganisms caused no effects above the trigger value of 25% deviation from the control. Thus, all available terrestrial toxicity tests show no effects on terrestrial organisms.
In accordance with Annex IX, column 2 of Regulation (EC) No 1907/2006, toxicity testing with terrestrial organisms does not need to be conducted as the Chemical Safety Assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate a need for further investigations.
Due to a low potential for adsorption and persistence, terrestrial toxicity tests showing no effects, unlikely direct and indirect exposure and no risk for the terrestrial compartment (RCR < 1) in the screening assessment, no toxicity testing for terrestrial plants needs to be conducted.
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