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Diss Factsheets
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EC number: 231-104-6 | CAS number: 7439-95-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- A single dose toxicity study of magnesium sulfate in rats and dogs
- Author:
- Mochizuki M, Akagi K, Inoue K and Shimamura K
- Year:
- 1 998
- Bibliographic source:
- The journal of toxicological sciences 23(Supp 1): 31-35
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Magnesium sulphate was infused for 6 hours intravenously in dogs.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Magnesium sulfate
- IUPAC Name:
- Magnesium sulfate
- Reference substance name:
- Magnesium sulphate
- EC Number:
- 231-298-2
- EC Name:
- Magnesium sulphate
- Cas Number:
- 7487-88-9
- IUPAC Name:
- 7487-88-9
- Test material form:
- solid - liquid: suspension
- Remarks:
- migrated information: dispersion
- Details on test material:
- - Molecular formular: MgSO4
- Supplier: Fukuda Pharmaceutical company, Japan
- Lot No.: 5F1122
- Purity: 99.87%
- Storage condition: Not reported
Constituent 1
Constituent 2
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-The dogs were 6 months of age.
- Fasting period before study: Not reported
- Housing: Metallic cage
- Diet (e.g. ad libitum): Solid feed
- Water (e.g. ad libitum): Tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 26 °C
- Humidity (%): 30 to 70 %
- Air changes (per hr): 10 to 15 hours
- Photoperiod (hrs dark / hrs light): 12 / 12 hours
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: 10% Glucose
- Details on exposure:
- Magnesium sulphate was infused for 6 hours at doses of 75, 300 and 1200 mg/kg (12.5, 50 and 200 mg/kg/hr)
- Doses:
- Magnesium sulphate was infused for 6 hours at doses of 75, 300 and 1200 mg/kg (12.5, 50 and 200 mg/kg/hr)
- No. of animals per sex per dose:
- The dogs were 6 months of age/female
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1 2, 3, 7, 10 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight - Statistics:
- LD50 and 95% Confidence Limits : Van der Waerden method
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred in any dose group
- Clinical signs:
- Vomiting, decreased spontaneous movement, staggering gait, prone position and flush of the conjunctiva and ear auricles were observed in the 1200 mg/kg group. The animals returned to a normal state by 1 hour after dosing.
- Body weight:
- There were no changes in body weight.
- Gross pathology:
- There were no changes in gross pathology.
- Other findings:
- There were no changes in food consumption.
Applicant's summary and conclusion
- Conclusions:
- It can be concluded that the LD50 value for magnesium sulfate adminstered intravenously is greater than 1200 mg/kg (200 mg/kg/hr).
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