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Diss Factsheets
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EC number: 401-990-0 | CAS number: 106990-43-6 CHIMASSORB 119; LOWILITE 19
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.6 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Species:
- guinea pig
- Strain:
- Pirbright-Hartley
- Sex:
- not specified
- Concentration / amount:
- Concentration of test material and vehicle used at induction:
First induction (intradermal injection): 1% in sesame oil and adjuvant saline mixture.
Second induction (epidermal application): 10% in vaseline
Concentration of test material and vehicle used for each challenge: 0.3 % in vaseline - Concentration / amount:
- Concentration of test material and vehicle used at induction:
First induction (intradermal injection): 1% in sesame oil and adjuvant saline mixture.
Second induction (epidermal application): 10% in vaseline
Concentration of test material and vehicle used for each challenge: 0.3 % in vaseline - No. of animals per dose:
- Number of animals in test group: 20
Number of animals in negative control group: 10 - Reading:
- other: each challenge
- Group:
- test chemical
- Total no. in group:
- 20
- Clinical observations:
- Evidence of sensitisation of each challenge concentration: 60- 75% of the animals were sensitized under the experimental conditions employed.
- Remarks on result:
- other: Reading: other: each challenge. Group: test group. Total no. in groups: 20.0. Clinical observations: Evidence of sensitisation of each challenge concentration: 60- 75% of the animals were sensitized under the experimental conditions employed..
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is classified as a skin sensitizer.
Reference
At one hour a score of one was seen in one animal. No inflammation was observed between 24 and 72 hours.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Evidence of sensitisation of each challenge concentration: 60- 75% of the animals were sensitized under the experimental conditions employed.
The test substance required the classification as sensitiser.
It is classified in the Annex VI of Regulation no.1272/2008 with the reference number 613-078-00-1.
Migrated from Short description of key information:
The sensitisation potential was investigated following the EU Method B.6, performed more than 12 years ago, under GLP conditions.
Justification for selection of skin sensitisation endpoint:
Only one study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Justification for selection of respiratory sensitisation endpoint:
Endpoint not requested for the registered tonnage band .
Justification for classification or non-classification
Since 60- 75% of the animals showed evidence of sensitisation of each challenge concentration, under the experimental conditions
employed, the test substance need to be classified as skin sensitiser.
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