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Diss Factsheets
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EC number: 204-658-1 | CAS number: 123-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well described study
- Qualifier:
- according to guideline
- Guideline:
- other: Draize
- Principles of method if other than guideline:
- Three male and three female New Zealand White rabbits with 0.5 ml of n-butyl acetate applied to the clipped, intact skin under a gauze patch and loosely covered with impervious sheeting. The animals were restrained for the 4-hour exposure period. Excess liquid was removed at the end of the exposure period. Skin reactions were scored by the Draize method at one hour and 1, 2, 3, 7, 10 and 14 days post-exposure.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Amount / concentration applied:
- 0,5 ml
- Observation period:
- Skin reactions were scored by the Draize method at one hour and 1, 2, 3, 7, 10 and 14 days post-exposure.
- Number of animals:
- Three male and three female
- Irritation parameter:
- other: Mean Draize
- Basis:
- mean
- Score:
- 0
- Reversibility:
- fully reversible
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- not irritating
Reference
The four hour exposure did not cause erythema, edema, or any other signs of skin irritation. Mean Draize scores for erythema , eschar, and edema were 0.0 for all animals tested at all post-exposure intervals.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well described study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Draize method
- Principles of method if other than guideline:
- Three male and three female New Zealand White rabbits were dosed with either 0.1 or 0.005 ml of n-butyl acetate directly onto the eye. The eyelid was held together for one second. The eyes were scored by the Draize method at one and four hours, and 1, 2, 3, and 7 days after dosing. At the Day 1 observation time point, fluorescein staining was used to detect corneal injury.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Three male and three female New Zealand White rabbits
- Amount / concentration applied:
- dosed with either 0.1 or 0.005 ml of n-butyl acetate directly onto the eye
- Duration of treatment / exposure:
- The eyelid was held together for one second
- Observation period (in vivo):
- The eyes were scored by the Draize method at one and four hours, and 1, 2, 3, and 7 days after dosing. At the Day 1 observation time point, fluorescein staining was used to detect corneal injury.
- Number of animals or in vitro replicates:
- 6
- Remarks on result:
- other: see irritant/corrosive response data provide below
- Irritant / corrosive response data:
- Instillation of 0.1 ml of n-butyl acetate did not cause corneal injury in any of 6 eyes, although iritis (mean scores were 0.7 at 1 and 4 hours) was noted in the eyes of four animals and minor to moderate conjunctival irritation (mean scores were 1.3 , 1.7, and 2.7 for redness, chemosis, and discharge, respectively at 4 hours) developed in all 6 animals. All of these signs of irritation resolved within 48 hours of dosing. Instillation of 0.005 ml of n-butyl acetate did not cause corneal injury in any of 6 eyes, although mild iritis (mean score of 0.3 at 1 and 4 hours) was noted in the eyes of two animals and minor to moderate conjunctival irritation (mean scores of 1.5 , 0.7, and 1.5 for redness, chemosis, and discharge, respectively at 4 hours) developed in all 6 animals. These signs of irritation resolved within 24 hours in 2 of the six animals and within 48 hours in the remaining four animals.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- not irritating
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
best data available
Justification for selection of eye irritation endpoint:
best data available
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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