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EC number: 205-642-7 | CAS number: 144-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1940
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test is performed based on the scientific method
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 940
Materials and methods
- Objective of study:
- metabolism
- GLP compliance:
- no
Test material
- Reference substance name:
- Sulfapyridine
- EC Number:
- 205-642-7
- EC Name:
- Sulfapyridine
- Cas Number:
- 144-83-2
- Molecular formula:
- C11H11N3O2S
- IUPAC Name:
- 4-amino-N-pyridin-2-ylbenzenesulfonamide
- Test material form:
- not specified
- Details on test material:
- No data
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: rats and rabbits
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: oral
- Vehicle:
- not specified
- Details on exposure:
- No data
- Duration and frequency of treatment / exposure:
- 50 days; 10days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.500 g/kg (50days, rats)
121.7 mgm/243.3±8.0 g(10 days, rabbits)
0.75-1.0 g/kg (10 days, rabbits)
- No. of animals per sex per dose / concentration:
- 14 rats per dose (50days, rats)
5 rats per dose (10 days, rats)
2 rabbits (10 days, rabbits) - Control animals:
- no
- Positive control reference chemical:
- No
- Details on dosing and sampling:
- No data
- Statistics:
- No data
Results and discussion
Main ADME results
- Type:
- excretion
- Results:
- 55.4±5.0% (administrated for 10 days)
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- No data
- Details on excretion:
- average dose excreted daily(rats):55.4±5.0% for 10 days exposure.
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- No data
Applicant's summary and conclusion
- Conclusions:
- The average of percent of total drus excreted daily in conjugated form (the rats were administrated for 10 days) was 44.9 ±4.6 %.
In the orally administrated experiment for 50 days, the mean concentration of drug in blood of free form and conjugated form were 4.36±0.52 mgm.% and 2.62±0.19 mgm % respectively at 0.5 % group(% in food); 9.81±0.62% and 4.71 ±0.31mgm % respectively at 1.0 % group(% in food).
The amount of conjugated test subsatnce was 66% of the total in the 10 days rabbit test. - Executive summary:
Three experiments was performed to evaluate the metabolism of sulfapyridine to rats. In the first experiment, the test substance was administrated by feed to rats. 0.5% and 1% of the test substance in food was applied to rats. after 50 days, the concentration in blood of free form of test substance was 4.36(±0.52) mgm.% and 9.81(±0.62)mgm.% respectively in the two groups; the concentration in blood for conjugated form of test substance was 2.62±0.19mgm.% and 4.71 ±0.31mgm.% respectively in the two groups.
In the second experiment, the substance was administrated orally, 5 rats each recieved 500 mg/kg of free acid suspended in gum acecia solution as a single daily dose by stomach tube for 10 days. The percent of total drug excreted daily in conjugated form was 44.9( ± 4.6). In the third experiment, an aquueous suspension of test substance was injected intraperitoeally into 2 rabbits daily for 10 days. The dose of test substance given once daily was 750 to 1000 mg/kg. The amount of conjugated test subsatnce was 66% of the total.
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