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Diss Factsheets
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EC number: 230-525-2 | CAS number: 7173-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- No analytical dose verification
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Limit test:
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.057 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: "c"(calculated)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.029 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the 48 h EC50 was found to be 0.057 mg test substance/L (i.e. 0.029 mg a.i./L), with 95% confidence limits of 0.046 - 0.071 mg/L. The highest dose at which 100% immobilisation was observed was 0.32 mg/L.
- Executive summary:
A short-term toxicity study with aquatic invertebrates (Daphnia magna) was performed according to OECD Guideline 202 and EU Method C.2, in compliance with GLP. Twenty daphnids per concentration were exposed for 48 h to 0.0032, 0.0056, 0.010, 0.018, 0.032, 0.056, 0.20 or 0.32 mg/L of the test substance (containing 50% a.i.). The test was carried out under static conditions. no analytical dose verification was conducted. The results were therefore expressed as nominal concentrations. Under the study conditions, the 48 h EC50 was found to be 0.057 mg test substance/L (i.e. 0.029 mg a.i./L), with 95% confidence limits of 0.046 - 0.071 mg/L. The highest dose at which 100% immobilisation was observed was 0.32 mg/L (Douglas and Handley, 1988).
Reference
48hr-EC50 = 0.057 mg/l, with 95% confidence limit 0.046-0.071 mg/L. The highest dose at which 100% immobilisation was observed was 0.32 mg/L.
Description of key information
- Key value from Registrant: 48 h EC50 = 0.029 mg a.i./L
- Key value from DDAC biocides assessment report for Product Type 8 (June 2015): 48 h EC50 = 0.062 mg a.i./L
In the present report, the 48 h EC50 of 0.062 mg a.i./L was selected as key value, in line with the methodology followed in the DDAC biocides assessment report for Product Type 8.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.062 mg/L
Additional information
A short-term toxicity study with aquatic invertebrates (Daphnia magna) was performed according to OECD Guideline 202 and EU Method C.2, in compliance with GLP. Twenty daphnids per concentration were exposed for 48 h to 0.0032, 0.0056, 0.010, 0.018, 0.032, 0.056, 0.20 or 0.32 mg/L of the test substance (containing 50% a.i.). The test was carried out under static conditions. no analytical dose verification was conducted. The results were therefore expressed as nominal concentrations. Under the study conditions, the 48 h EC50 was found to be 0.057 mg test substance/L (i.e. 0.029 mg a.i./L), with 95% confidence limits of 0.046 - 0.071 mg/L. The highest dose at which 100% immobilisation was observed was 0.32 mg/L (Douglas and Handley, 1988).
The DDAC biocides assessment report for Product Type 8 conducted under Directive 98/8/EC (evaluating Competent Authority: Italy, June 2015, attached in Section 13 of the IUCLID dataset), reported an additional study on DDAC, apart from the above EQC study. This study, seen as more reliable as it included an analytical dose verification, resulted in a 48 h EC50 = 0.062 mg a.i./L. The RMS considered the value from this study as the endpoint for the product authorisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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