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EC number: 226-242-9 | CAS number: 5333-42-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October until November 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: - missing test substance characterisation
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: Hazardous Substances, Part. 191, section 11, FDA, Washington 1965
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: laboratory breed
- Age at study initiation: not mentioned
- Weight at study initiation: 2.3 - 2.8 kg
- Housing: single housing in stainless steel cages
- Diet (e.g. ad libitum): Altromin 2023, ad libitum, supplied by Altromin GmbH, Lage, Germany
- Water (e.g. ad libitum): Drinking water ad libitum
- Acclimation period: not mentioned
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 60 ± 3
- Air changes (per hr): not mentioned
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- open
- Preparation of test site:
- other: abraded and shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 and 2 ml per kg bw was applied undiluted with softly brush - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 0, 5, 15, 30 min, 1, 2, 4, 24, 48, 72, 96, 120, 144 and 168 h after application
- Number of animals:
- 36, two groups with intact and scarified skin, 3 female and male animals per group
- Details on study design:
- TEST SITE
- Area of exposure: 15*16 cm of shaved skin of the dorsal and lateral parts of the trunk of the animals
- coverage: approx. 10%
- Type of wrap if used: not used
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water
- Time after start of exposure: 24 hours
SCORING SYSTEM: according to Draize-Scheme (0-4)
Examination time points: Signs of erythema and oedema (skin-thickness in mm) were recorded. - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1.22
- Reversibility:
- fully reversible
- Remarks on result:
- other: 2 ml/kg bw, scarified skin
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1.22
- Reversibility:
- fully reversible
- Remarks on result:
- other: 2 ml/kg, intact skin
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: 1 ml/kg bw, scarified skin
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48 nad 72 hours
- Score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: 1 ml/kg, intact skin
- Irritant / corrosive response data:
- AVERAGE SCORE
- Erythema:
control group, scarified = 0, intact = 0;
2 ml test substance, scarified = 1.22, intact = 1.22;
1 ml test substance, scarified = 1, intact = 1.
- Edema:
control group, scarified = 3.67 mm, intact = 3.63 mm;
2 ml test substance, scarified = 3.93 mm, intact = 3.87 mm;
1 ml test substance, scarified = 3.77 mm, intact = 3.73 mm.
REVERSIBILITY: yes - Other effects:
- none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of this study, 2-octyldodecan-1-ol is slightly irritating to the skin.
- Executive summary:
Based on the results of this study, 2-octyldodecan-1-ol is slightly irritating to the skin.
Reference
Table 1: Irritant/corrosive response data (mean values)
Score at time point Reversibility |
2 ml/kg bw |
1 ml/kg bw |
control group |
|||
Erythema intact / scarified |
Edema (mm) intact / scarified |
Erythema intact / scarified |
Edema (mm)intact / scarified | Erythema intact / scarified | Edema (mm)intact / scarified | |
0 min |
0 / 0 |
3.6 / 3.6 |
0 / 0 | 3.7 / 3.6 | 0 / 0 | 3.6 / 3.6 |
5 min |
0.2 / 0.2 |
3.7 / 3.8* |
0.3 / 0.3 | 3.7 / 3.7 | 0 / 0.2 | 3.6 / 3.6 |
15 min |
0.7 / 0.5 |
3.7 / 3.8* |
0.8 / 0.8 | 3.8* / 3.7 | 0 / 0.2 | 3.6 / 3.6 |
30 min |
1.2 / 1.0 |
3.8 / 3.9* |
1.2 / 1.2 | 3.7 / 3.7 | 0 / 0 | 3.6 / 3.6 |
1 h |
1.2 / 1.2 |
3.9* / 3.9 |
1.5 / 1.3 | 3.8* / 3.7 | 0 / 0 | 3.6 / 3.7 |
2 h |
1.3 / 1.3 |
3.8 / 4.0* |
1.3 / 1.7 | 3.8* / 3.7 | 0.2 / 0 | 3.6 / 3.6 |
4 h | 1.5 / 1.7 | 3.9* / 4.0* | 1.7 / 1.8 | 3.7 / 3.8 | 0.2 / 0 | 3.6 / 3.7 |
1 d | 1.7 / 1.5 | 4.0* / 4.1* | 1.7 / 1.5 | 3.8 / 3.7 | 0 / 0 | 3.7 / 3.7 |
2 d | 1.0 / 1.2 | 3.8 / 3.9* | 1.0 / 1.2 | 3.7 / 3.8* | 0 / 0 | 3.6 / 3.6 |
3 d | 1.0 / 1.0 | 3.8 / 3.8 | 1.0 / 1.0 | 3.7 / 3.8 | 0 / 0 | 3.6 / 3.7 |
4 d | 0.7 / 1.0 | 3.8 / 3.8* | 0.8 / 0.7 | 3.7 / 3.7 | 0.2 / 0 | 3.8 / 3.6 |
5 d | 0.2 / 0.3 | 3.7 / 3.8* | 0.2 / 0.5 | 3.8 / 3.7 | 0 / 0 | 3.7 / 3.6 |
6 d | 0.2 / 0.2 | 3.8 / 3.7 | 0 / 0.2 | 3.7 / 3.7 | 0 / 0 | 3.7 / 3.6 |
7 d | 0 / 0 | 3.6 / 3.7 | 0 / 0 | 3.7 / 3.7 | 0 / 0 | 3.7 7 3.7 |
Reversibility | c. | c. | c. | c. | c. | c. |
Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible
* = signficanctly difference to control group p ¿ 0.01
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: - missing test substance characterisation
- Qualifier:
- according to guideline
- Guideline:
- other: Hazardous Substances, Part. 191, section 12, FDA, Washington 1965
- Deviations:
- no
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: laboratory breed
- Age at study initiation: not mentioned
- Weight at study initiation: 2.3 - 2.8 kg
- Housing: single housing in stainless steel cages
- Diet (e.g. ad libitum): Altromin 2023, ad libitum, supplied by Altromin GmbH, Lage, Germany
- Water (e.g. ad libitum): Drinking water ad libitum
- Acclimation period: not mentioned
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 60 ± 3
- Air changes (per hr): not mentioned
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: treatment of the second eye with 0.9 % NaCl solution
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 ml - Duration of treatment / exposure:
- single administration, in each animal the test article was introduced into the conjunctival sac of the left eyes, afterwards the eyelid was closed for 1 second. Unlimited exposure (not rinsed).
- Observation period (in vivo):
- 4 days (oberservations after 5, 15, 30 min, 1, 2, 4 h, 1, 2, 3 and 4 d)
- Number of animals or in vitro replicates:
- 6 (3 male and 3 female)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no
SCORING SYSTEM: according to Draize-Scheme (0-4)
TOOL USED TO ASSESS SCORE: slit lamp; treatment with Na-fluorescein, USP 24 hours after administration - Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- AVERAGE SCORE
- Cornea: 0.0
- Iris: 0.0
- Conjuntivae (Redness): 0.33
- Conjuntivae (Chemosis): 0.0
DESCRIPTION OF LESIONS: In the area of the conjunctiva observed a slight erythema after 5 min, the maximum score was 1 hour after application.
REVERSIBILITY: reversible within 48 h after application - Other effects:
- none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the result of this study, 2-Octyldodecan-1-ol is slightly irritating to the eyes.
- Executive summary:
Based on the result of this study, 2-Octyldodecan-1-ol is slightly irritating to the eyes.
Reference
Table 1: Irritant/corrosive response data at each observation time
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae |
Chemosis |
|
5 min |
0 (6) |
0 (6) |
1 (6) |
0 (6) |
|
15 min |
0 (6) |
0 (6) |
1 (6) |
0 (6) |
|
30 min |
0 (6) |
0 (6) |
2 (5) / 1 (1) |
1 (5) / 0 (1) |
|
1 h |
0 (6) |
0 (6) |
2 (6) |
1 (6) |
|
2 h |
0 (6) |
0 (6) |
2 (6) |
1 (6) |
|
4 h |
0 (6) |
0 (6) |
2 (3) / 1 (3) |
0 (6) |
|
8 h |
0 (6) |
0 (6) |
2 (2) / 1 (4) |
0 (6) |
|
24 h |
0 (6) |
0 (6) |
1 (6) |
0 (6) |
|
48 h | 0 (6) | 0 (6) | 0 (6) | 0 (6) | |
72 h | 0 (6) | 0 (6) | 0 (6) | 0 (6) | |
4 d | 0 (6) | 0 (6) | 0 (6) | 0 (6) | |
Average 24, 48, 72 h | 0 | 0 | 0.33 | 0 | |
Reversibility * | c. | c. | c. | c. |
* Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute skin irritation studies with Guerbet alcohols have been conducted in both humans and rabbits. In rabbits 6 respresentatives of the category of Guerbet alcohols showed only slight irritant effects. Studies in human volunteers showed no irritant effects.
Data on eye irritation are available for 6 respresentatives of the category. All substances showed only slight irritant effects in the rabbit eye.
No data on respiratory irritation are available for any substance of the category.
Effects on skin
irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
The available data are conclusive but not sufficient for classfication of 2 -octyl-dodecan-1-ol with regard to irritation/corrosion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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