Registration Dossier
Registration Dossier
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EC number: 203-305-9 | CAS number: 105-53-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- MALONIC ACID DIESTERS Dimethylmalonate, 108-59-8 Diethylmalonate, 105-53-3
- Year:
- 2 005
- Bibliographic source:
- OECD SIDS
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as described by Smyth et al., Amer. Ind. Hyg. Assoc. J. 23, 95-107
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethyl malonate
- EC Number:
- 203-305-9
- EC Name:
- Diethyl malonate
- Cas Number:
- 105-53-3
- Molecular formula:
- C7H12O4
- IUPAC Name:
- diethyl malonate
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Amount / concentration applied:
- 0.01 ml diethyl malonate
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- animal:
- Score:
- 2
- Max. score:
- 10
- Remarks on result:
- probability of weak irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The irritation grade was determined to be 2 of 10. The GHS criteria for a classification are not met.
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