Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 211-477-1 | CAS number: 647-42-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Based on the liver effects (weight, clinical pathology, and histopathological changes) observed in female mice at ≥25 mg/kg/day, as well as teeth effects (microscopic changes) observed in male and female mice at 100 mg/kg, after approximately 70 days of dosing in the 1-generation mouse gavage study, the test substance is classified as Xn; R48/22 (Harmful: danger of serious damage to health by prolonged exposure if swallowed) according to EU Directive 67/548/EEC and STOT Rep Cat 2 (H373: May cause damage to organs [liver; teeth] through prolonged or repeated oral exposure) according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
