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EC number: 206-056-4 | CAS number: 298-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
For bis(2-ethylhexyl) hydrogen phosphate the most reliable and sensitive toxicity value on Daphnia magna is 48h-LC50 of 60.7 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 60.7 mg/L
Additional information
For bis(2-ethylhexyl) hydrogen phosphate two tests assessing the toxicity towards aquatic invertebrates are available.
The most reliable and sensitive toxicity value is obtained in a static test, where Daphnia magna was exposed to bis(2-ethylhexyl) hydrogen phosphate for 96 hours. The experiment was designed to reveal possible influence of two alternate procedures for preparation of test solutions. Acetone was used as co-solvent and also added to the control. There was no guideline stated but the test was performed in Standard Reference Water as recommended by ISO (1977) under generally accepted scientific principles and is widely in accordance with OECD guideline 202. The deviation was that the neonates were less than 66 h old instead less than 24 h. The test was conducted with 9 - 14 animals in duplicate or triplicate at a temperature of 20 +/-0.5°C. The pH was in the range of 8.0 - 8.4. Dead and life animals were recorded after 3, 24, 48, 72 and 96 h. The animals were classified as dead when their second antenna did not move within 15s after irrigation. Other reactions of the animals like swimming at the surface and general activity (swimming or resting) were also recorded. Analytical monitoring was not carried out. LC50 values and 95 % confidence limits were calculated using probit analysis. The values at 72h and 96h are not taken into account for assessment as for daphnids a test duration of 48 hour is standard (Guidance R.7b, ECHA, 2012). Using acetone, a 48h-LC50 of 60.7 mg/l was obtained. A 48h-LC50 of 80.3 mg/l is obtained without the use of acetone. Thus, addition of acetone to a final concentration of 0.5 mL/L (0.025% v/v) was not found to have an influence to results. ). Despite no details on amount of test concentrations were reported and the age of daphnids is > 24 h, the study was considered as sufficiently reliable to serve as key study.
In the second test, with a static test system a 48h-LC50 of > 42 mg/L related to nominal concentrations was observed on Daphnia magna. The LC50 was above the highest concentration tested. There was no guideline stated but the test was performed in Standard Reference Water as recommended by ISO (1977) under generally accepted scientific principles. Neonates (< 24h old) were exposed to bis(2-ethylhexyl) hydrogen phosphate. The test was performed with 9 - 12 concentrations and a control with 12 - 15 animals. The pH was in the range of 7.8 - 8.2 and the temperature was 20 - 23°C. Acetone was used as co-solvent and also added to the control (0.025% v/v). No analytical monitoring was carried out. Despite no details on amount of test concentrations were reported the study was considered as reliable and useful for assessment as a supporting study.
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