Registration Dossier
Registration Dossier
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EC number: 201-718-9 | CAS number: 87-02-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data from peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP
- Author:
- GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER
- Year:
- 1 994
- Bibliographic source:
- Chemosphere. Vol. 28, No. 12, pp. 2203.2236, 1994
- Reference Type:
- secondary source
- Title:
- 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Author:
- BG Chemie
- Year:
- 2 000
- Bibliographic source:
- BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of the test chemical in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 201-718-9
- EC Name:
- 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 87-02-5
- Molecular formula:
- C10H9NO4S
- IUPAC Name:
- 7-amino-4-hydroxynaphthalene-2-sulfonic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Molecular formula: C10H9NO4S
Molecular weight: 239.25g/mol
Substance type: organic
Physical state: solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 50 mg
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No Irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- In an eye irritation study, approx. 50mg of test chemical was instilled into the eyes of the rabbits. No eye irritation was observed after 7 days. Hence the test chemical was considered as non-irritant to rabbit eyes.
- Executive summary:
An eye irritation test was conducted in rabbits for test chemical to assess the eye irritation potential.
In this study, 50 mg of test chemical was instilled into the conjunctival sac of 2 animals and animals were observed for 7 days.
No eye irritation was observed after 7 days. Hence the test chemical was considered as non-irritant to rabbit eyes.
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