Registration Dossier
Registration Dossier
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EC number: 205-775-0 | CAS number: 150-84-5
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: data from secondary source with limited documentation
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Appraisal of sensitizing powers by maximization testing in humans
- Author:
- Kligman A.M.
- Year:
- 1 971
- Bibliographic source:
- cited in the RIFM/FEMA Database, Location 1805
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs: citronellyl acetate
- Author:
- Kligman
- Year:
- 1 973
- Bibliographic source:
- cited in: Food Cosmet. Toxicol., 11, 1973, 1069
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Human maximization test
- GLP compliance:
- no
Test material
- Reference substance name:
- Citronellyl acetate
- EC Number:
- 205-775-0
- EC Name:
- Citronellyl acetate
- Cas Number:
- 150-84-5
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yl acetate
- Test material form:
- not specified
- Details on test material:
- No additional details provided.
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 25
- Sex: male - Route of administration:
- dermal
- Details on study design:
- ADMINISTRATION
- Type of application: occlusive
- Vehicle / solvent: petrolatum
- Concentrations: 4%
- Testing schedule: 5 alternate-day 48 h periods; then 10 d rest period; challenge for 48 h on fresh site; evaluation after patch removal and 24 h thereafter
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: no effects observed
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0/25
- Number of subjects with negative reactions: 25/25
- Number of subjects with equivocal reactions: 0/25
- Number of subjects with irritating reactions: 0/25
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
