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EC number: 237-388-8 | CAS number: 13769-43-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-12-11 to 1992-01-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 1991-07-25
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- potassium vanadium trioxide
- IUPAC Name:
- potassium vanadium trioxide
- Reference substance name:
- Potassium vanadium trioxide
- EC Number:
- 237-388-8
- EC Name:
- Potassium vanadium trioxide
- Cas Number:
- 13769-43-2
- Molecular formula:
- KVO3
- IUPAC Name:
- potassium vanadium trioxide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Potassium metavanadate
- Physical state: light-grey, solid amorphous fine powder
- Storage condition of test material: at room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - Sprague-Dawley/ Tif:RAI f (SPF)
- Source: Lippische Versuchstierzucht, HAGEMANN GmbH, D-4923 Extertal 1
- Age at study initiation: approximately. 40 - 60 days
- Weight at study initiation: males: 164 - 194 g; females: 168 - 200 g
- Fasting period before study: food was discontinued approximately 16 hours before exposition.
- Housing: granulated textured wood (type 2, supplied by: Johannes Brandenburg, D-2849 Goldenstedt) was used as bedding material. During the 14- day observation period the animals were kept in groups of two or three in MAKROLON cages (type III).
- Diet (ad libitum): standardized diet for rats ALTROMIN 1324 (supplied by: ALTROMIN GmbH, D-4937 Lage/Lippe)
- Water (ad libitum): tap water
- Quarantine period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22°C ± 3°C (maximum range)
- Relative humidity: 60% ± 20% (maximum range)
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus/Exposure chamber volume/Method of holding animals in test chamber: the study was carried out using a dynamic inhalation apparatus with a nose only exposure of the animals according to KIMMERLE & TEPPER (RHEMA-LABORTECHNIK, D-6238 Hofheim/Taunus).
The apparatus consists of a cylindrical exposure chamber (volume 40 L) which holds a maximum of 20 animals in pyrex tubes at the edge of the chamber in a radial position.
- System of generating particulates/aerosols: the dust was generated with a dust generator and dosing apparatus (BURGHART, D-2000 Wedel/Holstein). The generator was fed with compressed air from a compressor. At the bottom of the exposure chamber the air was sucked off at a lower rate as created by the dust generator in order to produce a slight positive pressure in the exposure chamber.
Different concentrations were established by means of a combination of different settings of the dosing apparatus and air flow rates at the entrance.
- Method of particle size determination: an analysis of the particle size distribution was carried out twice during the exposure period using a cascade impactor according to MAY (1975) (MAY, K.R. 'Aerosol impaction jets', J. Aerosol Sci. 6, 403 (1975), RESEARCH ENGINEERS Ltd., (UK)-London N1 5RD). At the highest concentration only one measurement was performed because all animals died prematurely until 170 minutes after start of exposure.
The dust from the exposure chamber was sucked through the cascade impactor for 0.5 to 3 minutes at a constant flow rate of 5 L/min.The slides were removed from the impactor and were weighed on an analytical balance (SARTORIUS, type 1601 004, precision 10 µg).
The mass median aerodynamic diameter (MMAD) was estimated by means of nonlinear regression analysis (LITCHFIELD & WILCOXON). The 32 µm particle size range was not included in the determination of the MMAD in order not to give undue weight to this value.
- Temperature, humidity, air flow: air-flow meters (Rotameter, ROTA Apparate- und Maschinenbau, D-7867 Wehr 2/Baden) were used to control the constant supply of compressed air and vaccum. Flow rats were checked at least once/hour and corrected if necessary. Air changes per hour were 17.8 to 22.4.
The temperature (GTH 1200 Digital Thermometer, Fa. Greisinger Electronic GmbH, D-8413 Regenstauf) and humidity ( Sekunden-Hygrometer Typ 6100, Testoterm) were continuously monitored close to the nose of the animals in the inhalation chamber. The temperature was 22°C ± 3°C and the relative humidity was 60% ± 20%.
Exposition started by locating the rats into the exposure chamber.
TEST ATMOSPHERE
- Brief description of analytical method used: the dust concentration in the inhalation chamber was measured with an air sample filter (Minisart N SM 17598; 0.45 µm) and pump (water jet air pump controlled by a rotameter). Dust samples were taken during the first half and during the second half of the exposure. Air was sucked through at the constant flow of air of 5 L/min for 0.5 to 2 minutes. The filters were weighed before and after sampling (accuracy 0.01 mg). Concentration of the test substance in the air was calculated as mg/L.
- Samples taken from breathing zone: yes
TEST ATMOSPHERE
- MMAD (Mass median aerodynamic diameter):
0.52 mg/L air: 8.45 µm
0.90 mg/L air: 3.50 µm
2.02 mg/L air: 3.36 µm
4.79 mg/L air: 7.16 µm
9.66 mg/L air: 17.28 µm
- Respirable amount (particle size ≤4 µm):
0.52 mg/L air: 0.17 mg/L air
0.90 mg/L air: 0.48 mg/L air
2.02 mg/L air: 0.87 mg/L air
4.79 mg/L air: 1.68 mg/L air
9.66 mg/L air: 1.77 mg/L air - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- refer to "Details on inhalation exposure" above
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal concentrations:
male and female rats: 0.5, 1.0, 2.0 and 5.0 mg/L air
female rats only: 10.0 mg/L air
Actual concentrations:
male and female rats: 0.52 ± 0.24, 0.90 ± 0.47, 2.02 ± 0.29and 4.79 ± 0.69mg/L air
female rats only: 9.66 ± 0.71 mg/L air - No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: during and following exposure, observations were made and recorded systematically; individual records were maintained for each animal. A careful clinical examination was made at least once each day until all symptoms subsided, thereafter each working day.
Observations on mortality were made at least once daily with appropriate actions taken to minimize loss of animals to the study, e.g. necropsy or refrigeration of those animals found dead and isolation or sacrifice of weak or moribund animals.
Individual body weights of the animals were determined before the exposure, after 1 week and at study termination.
- Necropsy of survivors performed: yes; necropsy of all animals was carried out and all gross pathological changes were recorded. From animals which survived 24 hours or longer a microscopic examination of all organs which showed evident lesions was performed. - Statistics:
- The LC50 (14 days) was calculated by regression analysis according to FINNEY.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1.85 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- 1.18 - 2.9
- Exp. duration:
- 4 h
- Remarks on result:
- other: Slope: 3.964
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 4.16 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- 2.64 - 6.56
- Exp. duration:
- 4 h
- Remarks on result:
- other: Slope: 3.829
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2.89 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- 1.98 - 4.23
- Exp. duration:
- 4 h
- Remarks on result:
- other: Slope: 3.042
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 0.52 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC0
- Effect level:
- 0.9 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 0.52 mg/L air: no mortality
0.90 mg/L air: one male died 4 days after start of exposure
2.02 mg/L air: 2 males and 1 female died 3 days after start of exposure
4.79 mg/L air: all males and 2 females died approximately 3 hours and 5 days after start of exposure
9.66 mg/L air: all females died between 73 and 170 minutes after start of exposure - Clinical signs:
- other: 0.52, 0.90, 2.02 and 9.66 mg/L air: no signs of systemic intolerance 4.79 mg/L air: piloerection, ptosis and autoaggression (both fore feet wounded on test days 5 and 6) and haemochromodacryorrhoea immediately after end of exposure in 1 female Surviving a
- Body weight:
- Slight inhibition of body weight was observed in male and female rats at the 2.02 mg/L air dose level.
Moderate inhibition of body weight gain in 1 female animal at the 4.79 mg/L air dose level. - Gross pathology:
- 0.52 and 0.90 mg/L air: no pathological findings
Animals that died prematurely:
2.02 mg/L air: 1/1 female had a nose with haemorrhagic incrustation
4.79 mg/L air: 4/5 males had haemorrhagic lungs; 3/5 males had lungs with dark-red foci; 1/5 male had a dark coloured liver; 2/2 females had haemorrhagic lungs with dark-red foci; 1/2 female had a dark coloured liver
9.66 mg/L air: 5/5 females had lungs with fine reddish foci
These changes can be regarded as unspecific effects which usually occur after the inhalation exposure to a dust.
All further deceased animals showed no pathological findings.
Surviving animals (sacrificed) (males and females):
no pathological findings
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the EC-Commission Directive 67/548/EEC and its subsequent amendments, the test substance is classified as harmful by inhalation.
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is classified as Category 4.LC50 (male rats): 1.85 mg/L air (analytical)
LC50 (female rats): 4.16 mg/L air (analytical)
LC50 (male and female rats): 2.89 mg/L air (analytical)
The no-effect-level was 0.52 mg/L air for males and 0.90 mg/L air for females.
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