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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: secondary information made available in a report of "Berufsgenossenschaft der chemischen Industrie", 2000

Data source

Reference
Reference Type:
secondary source
Title:
Tetrafluoroboric acid and its salts - Toxicological evaluation
Author:
Anonymous
Year:
2000
Bibliographic source:
BG Chemie InfoCenter Toxikologische Bewertungen (www.bgchemie.de)
Report Date:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
A 51.5% aqueous solution of tetrafluoroboric acid was used for testing
Doses:
10, 100, 464 and 1000 mg/kg body weight
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 464 - <= 1 000 mg/kg bw
Based on:
dissolved
Remarks on result:
other: The doses refers to 51.5% of an aqueous tetrafluoroboric acid solution
Mortality:
The signs of toxicity were reversible after 24 hours
Clinical signs:
The 10 mg/kg body weight dose was tolerated without signs of toxicity. Following 100 mg/kg body weight, dyspnoea, sedation and lack of appetite were observed, and in the males, half-closed eyes. The signs of toxicity were reversible after 24 hours. Following 464 mg/kg body weight, signs of intoxication included dyspnoea, sedation, half or completely closed eyes, hyporeflexia, ataxia, body tremor, reduced muscle tone, squatting position and prone position, vocalisation, slightly reduced locomotor activity and glassy eyes, but the dose was survived by all rats. Following 1000 mg/kg body weight, all animals died within 24 hours. Autopsy of the deceased rats revealed oedematous and highly haemorrhagic gastrointestinal walls as well as blood-piebalded livers. Dissection of the surviving rats showed no treatment-related findings.
Body weight:
initial weights between 115 and 170 g

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information 51.5 % aqueous solution of tetrafluoroboric acid Criteria used for interpretation of results: EU
Conclusions:
The LD50 of 51-percent tetrafluoroboric acid was between 464 and 1000 mg/kg body weight and therefore, harmful if swallowed.