Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 438-910-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Emergency measure - Inhalation: Remove from exposure and keep patient at rest. Seek medical
attention.
Emergency measure - Eyes: Irrigate thoroughly with water for at least 15 minutes. Seek
immediate medical attention.
Emergency measure - Skin: Wash affected areas with water.
Emergency measure - Ingestion: Wash out mouth with water and give water to drink. Do not
induce vomiting. Seek medical attention.
Fire-fighting measures
Recommended extinguishing agent: Water spray, foam, dry powder or carbon dioxide.
Product arising from burning: Will burn emitting toxic fumes of oxides of nitrogen, carbon
monoxide and carbon dioxide.
Product determined by test: N
Protective equipment: Self-contained breathing apparatus must be worn for fire
fighting.
Accidental release measures
Emergency measures in case of spillage: In the event of a large spillage wear an air suit, rubber
gloves and rubber boots and carefully collect up the solid
and transfer to a sealed container. Wipe up any powder left
with a damp cloth and place in a container for disposal.
In the event of a small spillage wear laboratory coat, eye
protection, rubber gloves and if the spillage occurs outside
a fume cupboard, a dust respirator to FFP2S protection.
Collect up the solid carefully and transfer to a sealed
container. Wipe up any powder left with a damp cloth and
place in container for disposal.
Handling and storage
Handling: The material should be handled in closed containers where
possible, otherwise use appropriate local exhaust
ventilation or perform work in a fume cupboard. Care should
be taken to avoid the material entering the watercourse.
Storage: Store at ambient temperature in the dark. The substance
should be stored in the original container and be correctly
labelled and kept tightly closed.
Packaging of the substance and or preparation: UK-365,147 is packed in UN-approved fibre drums with an
inner plastic bag.
Transport information
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Marine transport (UN RTDG/IMDG)
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Air transport (UN RTDG/ICAO/IATA)
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Special provisions / remarks
- Remarks:
- Transport: Not classified as dangerous for carriage under the Carriage
of Dangerous Goods by Road and Rail (Classification,
Packaging and Labelling) and use of Transportable Pressure
Receptacles Regulations (CDGCDL) 1996.
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Stability and reactivity
Danger other than fire: None known.
Chemical reaction with water: None.
Dust explosion: No information is available on dust explosion risks.
Dust explosion determined by test: N
Disposal considerations
Industry - Possibility of recovery/recycling: Spilled material should be recovered and disposed of by
incineration.
Since the substance is a pharmaceutical intermediate, it is
completely converted during the production process of the
final drug, and hence there is nothing to recover.
Industry - Possibility of neutralisation: It is not possible to neutralise the substance.
Industry - Possibility of destruction: controlled discharge: None.
Industry - Possibility of destruction - incineration: Incineration is the preferred method of destruction.
Suitable abatement measures for oxides of sulphur and oxides
of carbon should be in place for incineration gases.
Industry - Possibility of destruction - water purification: None.
Industry - Possibility of destruction - other: None.
Public at large - Possibility of recovery/recycling: Not applicable as the substance will not enter the public
domain.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.