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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Remarks:
- Read across data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data was taken from secondary source
Data source
Reference
- Reference Type:
- other: Secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 17
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- OECD,SIDS,SIAM,2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1981
- Principles of method if other than guideline:
- - Principle of test: To determind the effect of chemical on eye
- Short description of test conditions: chemical is applied to lower eyelid of animal, commonly rabbit were used, effect of chemicalon cornea, irris and conjuctiva was noted
- Parameters analysed / observed: redness, edema - GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-aminopropyltriethoxysilane
- EC Number:
- 213-048-4
- EC Name:
- 3-aminopropyltriethoxysilane
- Cas Number:
- 919-30-2
- Molecular formula:
- C9H23NO3Si
- IUPAC Name:
- 3-AMINOPROPYLTRIETHOXYSILANE
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Not specified
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Lesser Ketones Manufacturing Association Leesburg, VA
- Age at study initiation: No data avaiable
- Weight at study initiation: No data avaiable
- Housing: No data avaiable
- Diet (e.g. ad libitum): No data avaiable
- Water (e.g. ad libitum): No data avaiable
- Acclimation period: No data avaiable
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data avaiable
- Humidity (%): No data avaiable
- Air changes (per hr): No data avaiable
- Photoperiod (hrs dark / hrs light): No data avaiable
IN-LIFE DATES: From: To:
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- Amount :0.1 ml
Concentration: undiluted - Duration of treatment / exposure:
- 72 hrs
- Observation period (in vivo):
- 14 days
- Duration of post- treatment incubation (in vitro):
- 8-14 days
- Number of animals or in vitro replicates:
- 9 animals
- Details on study design:
- Not specified
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Blistering of the conjunctivae
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Iritis, redness and chemosis was observe
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Corneal necrosis was observed for all animals at 24 hours to day 4, and persisted in three animals on days 13 and 14.
- Irritant / corrosive response data:
- Unwashed group:Corneal opacities were observed in two animals beginning at 48 hours, and were observed in all animals on days 7-14. Corneal necrosis was observed for all animals at 24 hours to day 4, and persisted in three animals on days 13 and 14. Iritis, redness and chemosis was observe in most or all animals by 24 hours, and persisted in at least one animal by day 13. Blistering of the conjunctivae and/or nictitating membrane as well as discoloration of the nictitating membrane was observed for all animals at 24 and 48 hours.
Washed group: Corneal opacities were observed in one animal beginning at 48 hours, and for all animals from 72 hours until day 14. Corneal necrosis was observed for all animals at 24 hours to day 7, and persisted in two animals on days 8 to 10. Iritis, redness and chemosis was observed in all animals by 24 to 48 hours, and persisted in at least one animal by day 13. Blistering of the conjunctivae and/or nictitating membrane was observed for all animals at 24 and 48 hours. Discoloration of the nictitating membrane was observed in one animal at 24 and 48 hours
Any other information on results incl. tables
The treated eyes of six animals remained unwashed. The treated eyes of three animals were washed for 1 minute approximately 5 seconds after installation of the test article. The eyes were scored at 24, 48, and 72 hours, and on days 4, 7, and 8-14 after dosing.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- An unfailing study, like OECD 405, found that test material was extremely irritating to the eye when in contact for 72 h in rabbits for 14 days.
- Executive summary:
An unfailing study, like OECD "Acute Eye Irritation/Corrosion" was performed for the RA chemical 3-aminopropyltriethoxysilane(CAS number: 919-30-2)using rabbits.
The RA chemical was applied to all the animals at a dose of 0.1ml to the lower eyelid of the animal, one eye serves as a control and the other eye serves as treatment Unwashed group: Corneal opacities were observed in two animals beginning at 48 hours and were observed in all animals on days 7-14. Corneal necrosis was observed for all animals at 24 hours to day 4 and persisted in three animals on days 13 and 14. Iritis, redness, and chemosis were observed in most or all animals by 24 hours and persisted in at least one animal by day 13. Blistering of the conjunctivae and/or nictitating membrane as well as discoloration of the nictitating membrane was observed for all animals at 24 and 48 hours.
Washed group: Corneal opacities were observed in one animal beginning at 48 hours, and for all animals from 72 hours until day 14. Corneal necrosis was observed for all animals at 24 hours to day 7 and persisted in two animals on days 8 to 10. Iritis, redness, and chemosis were observed in all animals by 24 to 48 hours and persisted in at least one animal by day 13. Blistering of the conjunctivae and/or nictitating membrane was observed for all animals at 24 and 48 hours. Discoloration of the nictitating membrane was observed in one animal at 24 and 48 hours. Hence the test material can be classified as irritating to the eye of the animals
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