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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Explosiveness
Administrative data
- Endpoint:
- explosive properties of explosives
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2021-06-17 to 2021-06-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.14 (Explosive properties)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
- Cas Number:
- 2270944-70-0
- Molecular formula:
- C15H16ClN5O4
- IUPAC Name:
- 4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch (Lot) Number: I20CD1048
- Purity/Composition: 100%
- Purity test date : 2020-05-11
- Expiry date: 2022-03-22 (retest date)
- Physical Description: Light yellow to dark orange solid
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions and during storage: not indicated
- Stability in the medium, i.e. sensitivity of the test material to hydrolysis and/or photolysis: not indicated
- Solubility and stability of the test material in the solvent/vehicle and the exposure medium: not indicated
- Reactivity of the test material with the incubation material used (e.g. plastic ware): not indicated
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
No treatment
Results and discussion
Small-scale preliminary testsopen allclose all
- Key result
- Parameter:
- sensitiveness to impact: impact energy (J)
- Remarks on result:
- not sensitive to impact using an impact energy of 40 J
- Remarks:
- The test item of JNJ-73848242-AAA (T003901) was observed to exhibit no reaction at 40 J.
- Key result
- Parameter:
- sensitiveness to friction: friction load (N)
- Remarks on result:
- not sensitive to friction using a friction load of 360 N
- Remarks:
- The test item of JNJ-73848242-AAA (T003901) was observed to exhibit no reaction at 360 N.
- Key result
- Parameter:
- thermal sensitivity - Koenen test: diameter of the orifice plate
- Remarks on result:
- thermal sensitive if heated under defined confinement
- Remarks:
- The test item did not exhibit an explosion during any of the tests.
Any other information on results incl. tables
- BAM FALLHAMMER: Test Procedure
The test item was placed in the impact device and the 10 kg weight dropped from a height of 40 cm which is equivalent to 40 J. If an "explosion" was observed, the impact energy was reduced to 7.5 J and further tests conducted.
Table 8:1: Test Results
Mass (kg) | Height (m) | Energy (J) | Test number and result* (X / ✓) | Comments |
10 | 0.4 | 40 | 1 2 3 4 5 6 X X X X X X | No reaction |
* ‘✓’ denotes an explosion (includes crackling, sparking, inflammation).
‘X’ denotes no reaction or decomposition (change in colour).
2. BAM FRICTION: Test procedure
Table 9:1: Test Results
Mass (kg) | Load (N) | Test number and result* (X / ✓) | Comments |
10 | 360 | 1 2 3 4 5 6 X X X X X X | No reaction |
* ‘✓’ denotes an explosion (includes crackling, sparking, inflammation).
‘X’ denotes no reaction or decomposition (change in colour).
3. KOENEN TUBE: Test procedure
Table 10:1 : Full test results
Mass of test item (g) | Orifice Diameter (mm) | Time for First Ignition (s) | Explosion (X / ✓)* |
16.3 | 6 | 14 | X |
16.3 | 6 | 15 | X |
16.3 | 6 | 15 | X |
16.3 | 2 | 10 | X |
16.3 | 2 | 11 | X |
16.3 | 2 | 11 | X |
* ‘✓’ denotes 3 or more fragments.
‘X’ denotes fewer than 3 fragments.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- BAM FALLHAMMER Test: The test item of JNJ-73848242-AAA (T003901) was observed to exhibit no reaction at 40 J. The test result is therefore considered Negative (-) (according to the EC
Classification, Packaging & Labelling of Dangerous Substances in the European Union
Part 2, Testing Methods, Jan 97).
BAM FRICTION Test: The test item of JNJ-73848242-AAA (T003901) was observed to exhibit no reaction at 360 N. The test result is therefore considered Negative (-) (according to the EC
Classification, Packaging & Labelling of Dangerous Substances in the European Union
Part 2, Testing Methods, Jan 97).
KOENEN TUBE Test: The test item did not exhibit an explosion during any of the tests. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging &
Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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