Registration Dossier
Registration Dossier
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EC number: 601-093-6 | CAS number: 111453-32-8
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- other: Expert Statement
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Expert statement
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test material
- Reference substance name:
- rac-5-Amino-N-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamic acid
- EC Number:
- 601-093-6
- Cas Number:
- 111453-32-8
- Molecular formula:
- C11 H11 I3 N2 O5
- IUPAC Name:
- rac-5-Amino-N-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamic acid
Constituent 1
Study design
- Estimation method (if used):
- comparison with the behavior of structurally related compound
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: estimation
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: estimation
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: estimation
Any other information on results incl. tables
Test substance (ZK 39211) | rac-5-Amino-N-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamic acid | ||
Analogous compound (ZK 39166)
| rac-N-(2,3-Dihydroxypropyl)-5-nitroisophthalamic acid | ||
Kinetic data for hydrolysis of ZK 39166 at 25 °C (Report A01762): | pH | statement | half-life,t1/2 |
| 4 7 9 | stable* stable* stable* | > 1 year > 1 year > 1 year |
| * Stable signifies that less than 10 % of the test substance were degraded during 5 days at 50 °C, corresponding to a half-life > 1 year at 25 °C. | ||
Applicant's summary and conclusion
- Executive summary:
On basis of the structural similarity of the test substance ZK 39211 with ZK 39166 (bears a nitro-instead of a amino-group at the benzene ring) hydrolytic stability is expected. The rate of hydrolysis of ZK 39166 was determined according to EC guideline C.7 at pH 4, 7 and 9. No hydrolytic degradation occurred within 5 days at pH 4, 7 and 9 at 50 +/- 0.1 °C. According to the EC test guideline, ZK 39166 can therefore be considered hydrolytically stable at pH 4, 7 and 9 (t1/2 > 1 year at 25 °C).
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