Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 427-370-1 | CAS number: 164288-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- 1-Propanaminium,3-(1-oxododecyl)-amino-N-(2-((2-hydroxyethyl)amino)-2-oxoethyl)-N,N-dimethyl is an UVCB which doesn't present any alerts in genotoxicity, systemic toxicity and isn't subject to any bioaccumulation potential. Thus, a toxicokinetic study might be unrealistical since producing the benchmarks for the test is a limitating factor.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Due to the cationic profile, a published article on cetrimonium bromide is a reliable data evidence to sustain our rational:
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Assessing the bioavailability of a cationic surfactant using radiolabeled element
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- other: oral and intraveneous
- Vehicle:
- water
- Remarks:
- Due to the high water solubility
- Details on exposure:
- 14C-labelled cetrimonium bromide: 0.8 mg/kg by oral gavage
14C-labelled laurtrimonium bromide: single intravenous injection of 0.5 ml of a 0.023% solution in saline - Preliminary studies:
- The conclusion from both studies are as follows:
1)-Cetrimonium bromide shows to be poorly absorbed in the gastro-intestinal tract and not readily metabolized in the rat body.
2)-Only small amounts of radioactivity were found in other organs and there was no sign of accumulation of radioactivity in any organ. - Conclusions:
- Interpretation of results (migrated information): other: Bioaccumulation is not expected
Based on the toxicological profile, one can assume that these common metabolites will be included in the physiologic processes and metabolised accordingly. Concerning excretion, an extensive metabolism, leading to polar metabolites with low molecular weights, followed by renal excretion is to be expected
Therefore there is no potential of bioaccumulation of the constituents of this mixture. - Executive summary:
The toxicokinetic evaluation of 1-Propanaminium,3-(1-oxododecyl)-amino-N-(2-((2-hydroxyethyl)amino)-2-oxoethyl)-N,N-dimethyl based both on its intrinsic profile and 2 published acticles corroborated with our assesment .
All taken togheter, one is confortable concluding that 1-Propanaminium,3-(1-oxododecyl)-amino-N-(2-((2-hydroxyethyl)amino)-2-oxoethyl)-N,N-dimethyl is not expected to bioaccumulate in the organisms.
Bartnik, F.G., and Wingen, F. (1979). Percutaneous absorption of dodecyltrimethylammonium bromide, a cationic surfactant, in the rat. Food Cosmet. Toxicol. 17, 633-637
Isomaa, B. (1975) Absorption, distribution and excretion of [14C]CTAB, a quaternary ammonium surfactant, in the rat. Fd. Cosmet. Toxicol. 13, 231-237
Data source
Materials and methods
Test material
- Reference substance name:
- -
- EC Number:
- 427-370-1
- EC Name:
- -
- Cas Number:
- 164288-56-6
- Molecular formula:
- C21H44N3O3Cl
- IUPAC Name:
- {[(2-hydroxyethyl)carbamoyl]methyl}dimethyl(3-octadecanamidopropyl)azanium chloride
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.