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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given; guideline study (OECD TG 202); test was performed by a laboratory with a high reputation for delivery of solid data.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Phenol, styrenated; Mono (or di or tri)-(alpha-methylbenzyl) phenol
- no further information - Analytical monitoring:
- yes
- Details on sampling:
- - no data reported
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- no further information - Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Nominal and measured concentrations:
- - graduate doses of test substance were applied. Individual concentrations are not reported.
- Details on test conditions:
- - no data reported
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.6 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Results are reported without any detail in databases (CHRIP/J-CHECK) of the National Institute of Technology and Evaluation (NITE) of Japan.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In a test according to OECD TG 202, the 48h EC50 of phenol, styrenated to daphnia was determined to be 4.6 mg/L.
Reference
Description of key information
Short-term toxicity of phenol, styrenated to aquatic invertebrates was tested in two studies according to OECD TG 202. Results (48h EC50) obtained fall into the same range below 5 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.6 mg/L
Additional information
For the substances phenol, styrenated and phenol, mono- & distyrenated, two acute daphnia immobilisation tests have been identified. One is a GLP conform study according to OECD TG 202 using Novares LS 500 as test substance (Heyner/BiLaCon 2000). Reliability is 2, as documentation is somewhat limited. A definite LD50 value was not reported. Therefore, the study is used as weight of evidence.
The second test was carried out for the National Institute of Technology and Evaluation/Ministry of the Environment of Japan and is reported in the Japanese databases CHRIP/J-CHECK (CHRIP/NITE 1997). The study was performed according to OECD TG 202, but reporting is very limited. Details on test performance and results are not available from the database, but a definite LD50 of 4.6 mg/L is reported. The substance tested was phenol, styrenated (CAS 61788-44-1). Composition of the test substance is not reported, but from the substance name under the Chemical Substance Control Law (mono- (or di- or tri-)-(alpha-methylbenzyl)phenol), it can be concluded that the test substance is a mixture of mono-, di-, and tristyrenated phenol. Similarity with Novares LS 500 is considered to be adequate to use data from this test as weight of evidence for characterisation of the short-term toxicity to aquatic invertebrates of phenol, mono- & distyrenated (Novares LS 500).
Heyner/BiLaCon 2000
Due to the limited solubility and multiconstituent composition of the test substance, the test was performed using water accommodated fractions. A 48h EL50 of >1 - <10 mg/L was determined (nominal loading).
Stability of the test substance was demonstrated by analytical measurements at day one and after 7 days. Dissolved concentrations of the test substance for different loadings were analysed as TOC in duplicate measurements. Loadings and measured concentrations are displayed in the following table.
Conversion to test substance concentrations was performed by applying a conversion factor of 1.163 resulting from the mean carbon content of the test substance (86.018 %) determined by carbon content and percentage of the individual components of phenol, mono- & distyrenated.
Loadings (mg substance/L) | 1 | 10 | 100 |
measured concentrations (mg TOC/L) | 0.5 | 4.5 | 40 |
Substance concentrations (mg/L) | 0.58 | 5.23 | 46.52 |
As is evident from the table, the 48h EC50 is in the range between >0.58 and <5.23 mg/L
CHRIP/NITE 1997
In this acute daphnia immobilisation test, EC50 (immobilisation) was determined.
48h EC50: 4.6 mg/L
The value of the NITE study is selected for further consideration.
As supporting evidence, read across from the substance LA 300 and LA 700 (phenol, methylstyrenated) was used. Transformation of loadings to measured concentration result in 48h EC50 values of about 1 mg/L which is in the same order of magnitude as for phenol, mono- & distyrenated.
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