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EC number: 457-320-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 22 September 1999 to 08 October 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- yes
- Remarks:
- no correction made for temperature and pressure difference between saturator column and flow meter
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes
- Type of method:
- gas saturation method
- Temp.:
- 30 °C
- Vapour pressure:
- 0.032 Pa
- Remarks on result:
- other: Measured
- Temp.:
- 40 °C
- Vapour pressure:
- 0.087 Pa
- Remarks on result:
- other: Measured
- Temp.:
- 50 °C
- Vapour pressure:
- 0.132 Pa
- Remarks on result:
- other: Measured
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.024 Pa
- Remarks on result:
- other: Estimated based on linear regression analysis of measured vapour pressure at temperatures of 30, 40 and 50 degrees centigrade
- Conclusions:
- In a GLP study conducted according to OECD Guideline 104, the estimated vapour pressure of EC# 434-650-5 test material at 25oC, based on linear regression analysis of the log p versus 1/T curve generated from measured vapour pressures at 30, 40 and 50oC, was 0.0236 Pa.
- Executive summary:
In a GLP study conducted according to OECD Guideline 104 and EC Method A.4, the vapour pressure of EC# 434-650-5 test material was determined by the gas saturation method. Briefly, the neat test material was coated onto glass beads, which were transferred to a saturator column and subject to a stream of inert carrier gas (N2) at a constant temperature (+/- 0.5 degrees centigrade). The resulting vapour-saturated gas was passed through XAD-2 sorbent tubes to absorb the MRD-99-422, which was then extracted with methylene chloride. Gas chromatography was used to determine the quantity of test substance transferred. Triplicate determinations were carried out at 30, 40 and 50oC. The gas flow rates were 100 ml/min at the two higher temperatures or 200 ml/min at the lowest temperature.
The mean vapour pressures at 30, 40 and 50oC were 0.0318, 0.0874 and 0.132 Pa, respectively. Based on linear regression analysis of the log p versus 1/T curve of these measurements, the estimated vapour pressure at 25oC is 0.0236 Pa.
- Endpoint:
- vapour pressure
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reason / purpose for cross-reference:
- read-across source
- Test no.:
- #1
- Temp.:
- 30 °C
- Vapour pressure:
- 0.032 Pa
- Test no.:
- #2
- Temp.:
- 40 °C
- Vapour pressure:
- 0.087 Pa
- Test no.:
- #3
- Temp.:
- 50 °C
- Vapour pressure:
- 0.132 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.024 Pa
- Remarks on result:
- other: estimated based on linear regression analysis from measured vapour pressures at 30, 40 and 50 degrees C
- Conclusions:
- In a GLP study conducted according to OECD Guideline 104 and EC Method A.4, the vapour pressure of EC# 434-650-5 test material was determined by the gas saturation method. Briefly, the neat test material was coated onto glass beads, which were transferred to a saturator column and subject to a stream of inert carrier gas (N2) at a constant temperature (+/- 0.5 degrees centigrade). The resulting vapour-saturated gas was passed through XAD-2 sorbent tubes to absorb the MRD-99-422, which was then extracted with methylene chloride. Gas chromatography was used to determine the quantity of test substance transferred. Triplicate determinations were carried out at 30, 40 and 50oC. The gas flow rates were 100 ml/min at the two higher temperatures or 200 ml/min at the lowest temperature.
The mean vapour pressures at 30, 40 and 50oC were 0.0318, 0.0874 and 0.132 Pa, respectively. Based on linear regression analysis of the log p versus 1/T curve of these measurements, the estimated vapour pressure at 25oC is 0.0236 Pa. - Executive summary:
In view of the structural and chemical similarities, it is considered that the results of this study can be used for read-across to EC# 457-320-2.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 March to 1 June 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- effusion method: vapour pressure balance
- Specific details on test material used for the study:
- Appearance: dark red paste
Storage conditions: Room temperature in the dark
Batch: NB 6786-35 - Key result
- Test no.:
- #3
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Key result
- Test no.:
- #4
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Test no.:
- #1
- Temp.:
- 25 °C
- Vapour pressure:
- 0.002 Pa
- Remarks on result:
- other: disregarded due to poor linear relationship and evidence of degassing
- Test no.:
- #2
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Disregarded due to poor linear relationship and evidence of degassing
- Conclusions:
- The vapour pressure of the test substance is 3.6 x 10-6 Pa at 25 degrees C.
- Executive summary:
The vapour pressure of a substance is defined as the saturation pressure above a solid or liquid substance. At the thermodynamic equilibrium, the vapour pressure of a pure substance is a function of temperature only.
The vapour pressure was determined using a vapour pressure balance. 0.35g of test substance was added to the furnace, the apparatus assembled and evacuated to a pressure of less than 1 x 10 -4 Torr. A series of 4 runs were performed between temperatures and 33 and 181 degrees C. As no condensation occurred, the vapour pressure is related to only to the observed mass difference.
The mean vapour pressure of 3.4 x 10 -6 Pa was obtained from two liner plots (runs 3 and 4) - runs 1 and 2 were disregarded due to the poor linear relationship obtained and evidence of degassing.
Therefore, the vapour pressure of the test substance is 3.4 x10 -6 Pa at 25 degrees C.
Based on the physical chemical similarities, this study is considered suitable for read-across to EC:457 -320 -2.
- Endpoint:
- vapour pressure
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Test no.:
- #1
- Temp.:
- 25 °C
- Vapour pressure:
- 0.002 Pa
- Remarks on result:
- other: Disregared due to poor linear relationship and evidence of degassing
- Test no.:
- #2
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Disregarded due to poor linear relationship and evidence of degassing
- Key result
- Test no.:
- #3
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Key result
- Test no.:
- #4
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure of the test substance is 3.4 x 10-6 Pa at 25 degrees C.
- Executive summary:
The vapour pressure of a substance is defined as the saturation pressure above a solid or liquid substance. At the thermodynamic equilibrium, the vapour pressure of a pure substance is a function of temperature only.
The vapour pressure was determined using a vapour pressure balance. 0.35g of test substance was added to the furnace, the apparatus assembled and evacuated to a pressure of less than 1 x 10 -4 Torr. A series of 4 runs were performed between temperatures and 33 and 181 degrees C. As no condensation occurred, the vapour pressure is related to only to the observed mass difference.
The mean vapour pressure of 3.4 x 10 -6 Pa was obtained from two liner plots (runs 3 and 4) - runs 1 and 2 were disregarded due to the poor linear relationship obtained and evidence of degassing.
Therefore, the vapour pressure of the test substance is 3.4 x10 -6 Pa at 25 degrees C.
Referenceopen allclose all
Runs 1 and 2 are disregarded due to the poor linear relationship obtained and evidence of degassing. The mean vapour pressure of 3.4 10 -6 Pa at 25 degrees C was obtained from runs 3 and 4.
Runs 1 and 2 are disregarded due to the poor linear relationship obtained and evidence of degassing. Therefore, the mean vapour pressure of 3.4 10 -6 Pa at 25 degrees C was obtained from runs 3 and 4.
Description of key information
There are 2 vapour pressure results available on EC: 434 -650 -5 which are considered suitable for read-across to EC: 457 -320 -2.
In a supporting GLP study (1999) conducted according to OECD Guideline 104, the estimated vapour pressure of EC# 434-650-5 test material at 25oC, based on linear regression analysis of the log p versus 1/T curve generated from measured vapour pressures at 30, 40 and 50oC, was 0.0236 Pa.
A key GLP study is available conducted according to OECD 104 (2000). The mean vapour pressure of 0.0000034 Pa on EC: 434 -650 -5 was obtained via vapour pressure balance method. This result can be read-across to EC: 457 -320 -2 and is used for the purposes of the chemical safety assessment.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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