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EC number: 415-890-1 | CAS number: 142770-42-1 QUANTACURE CPTX
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the studies on rabbits, 1-chlor-4-(n-propoxy)-5-thioxanthen-10-one is considered to be not skin or eye irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield (UK)
- Age at study initiation: 12-15 weeks
- Weight at study initiation: 2.9 - 3.3 kg
- Housing: individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19
- Humidity (%): 30-70
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 17 sept 1991 To: 20 sept 1991 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4h
- Observation period:
- 24h, 48h, 72h
- Number of animals:
- 3
- Details on study design:
- Approximately 24h prior to application of the test substance, hait was removed with electric clippers from the dorso-lumbar region of each rabbit exposing an area of skin approximately 100 mm x 100 mm.
1 0.5 g amount of the test substance was applied under a 25 mm x 25 mm gauze pad which had been moistened with 0.5 ml distilled water to one intact skin site on each animal.
Each treatment site was covered with Elastic adhesive dressing for a four hours period. The animals were not restrained during the exposure period and were returned to their cages immediately after treatment.
At the end of the exposure period, the semi-occulsive dressing and gauze pad were removed and the treatment site was washed with warm water (30-40°C) to remove any residual test substace. The treated area was blotted dry with absorbent paper.
All animals were observed daily for signs of ill health or toxicity.
Examination of the treated skin was made on Day 1 (i.e. approx 30 minutes after removal of the dressings) and on Days 2, 3, 4 (equivalent to 24, 48 and 72 hours). - Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no erythema or oedema observed in any animal at any observation stage.
- Other effects:
- no clinical signs observed
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not skin irritating
- Conclusions:
- A study was performed to assess the skin irritation potentialof CPTX. Three rabbits were each administered a single dermal dose of 0.5 g of the test substance and observed for a maximum of four days. No reactions were observed following a single semi-occlusive application of CPTX to intact rabbit skin for four hours.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Interfauna (UK)
- Age at study initiation: 14-15 weeks
- Weight at study initiation: 3.2 - 3.5 kg
- Housing: individually in metal cages with perforated floors.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19
- Humidity (%): 30-70
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 63 g
- Duration of treatment / exposure:
- only one exposure
- Observation period (in vivo):
- 4 days
- Number of animals or in vitro replicates:
- 3 rabbits
- Details on study design:
- The eyes of each animal were examined prior to instillation of the test substance to ensure that there was no pre-existing corneal damage, iradial or conjunctival inflammation.
One animal was treated in advance of the others, to ensure that if a severe response was produced, no furthe animals would be exposed.
Aproximately 63 mg of the test substance, the weight occupying a volume of 0.1 ml, was placed into the lower everted lid of one eye of each animal.
The eyelids were then gently held together for one second before releasing. The contralateral eye remained untreated.
All animals were observed for signs of ill health or toxicity.
Examination of the eyes was made after 1 hour, and 1, 2, 3 (equivalent to 24? 48, 72 hours after instillation) and 4 days after instillation. Observation of the eyes was aided by the use of a handheld light. - Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Temporary mild conjunctivial irritation (chemosis, redness) one hour after exposure (minimal score of 1), full reversible 24h after exposure.
No corneal damage or iridial inflammation was observed. - Other effects:
- There were no signs of toxicity or ill health.
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not eye irritating
- Conclusions:
- Based on these results, the test item is considered to slighlty irritating but not classified according to the CLP or GHS criteria.
- Executive summary:
A study was performed to assess the eye irritation potential of CPTX to the rabbit. Three rabbits were each administered a single ocular dose of 63 mg of the test substance and observed for a maximum of four days after instillation. A single instillation of CPTX into the eye of the rabbit elicited transient mild conjunctival inflammation only. All reactions had resolved one to two days after instillation. Based on these results, the test item is considered to slighlty irritating but not classified according to the CLP or GHS criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In vivo skin irritation (Huntingdon 1991)
A study was performed to assess the skin irritation potentialof CPTX. Three rabbits were each administered a single dermal dose of 0.5 g of the test substance and observed for a maximum of four days. No reactions were observed following a single semi-occlusive application of CPTX to intact rabbit skin for four hours.
In vivo eye irritation study (1991)
A study was performed to assess the eye irritation potential of CPTX to the rabbit. Three rabbits were each administered a single ocular dose of 63 mg of the test substance and observed for a maximum of four days after instillation. A single instillation of CPTX into the eye of the rabbit elicited transient mild conjunctival inflammation only. All reactions had resolved one to two days after instillation. Based on these results, the test item is considered to slighlty irritating but not classified according to the CLP or GHS criteria.
Justification for classification or non-classification
Based on the available data, no classification for irritation is required for 1-chlor-4-(n-propoxy)-5-thioxanthen-10-one according to the Regulation EC n°1272/2008.
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