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Diss Factsheets
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EC number: 401-610-3 | CAS number: 122012-52-6 GENIPLEX A
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-03-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: Schering Agrochemical standard Quality Control (QC) method of testing.
- Deviations:
- not specified
- GLP compliance:
- not specified
- Other quality assurance:
- other: The measurement of particle size distribution was made according to a Schering Agrochemical standard Quality Control (QC) method of testing.
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- other: not stated
- Mass median aerodynamic diameter:
- >= 14.32 - <= 18.84 µm
- Remarks on result:
- other: D(50%)
- Remarks:
- D(50%) µm = 18.49
- Percentile:
- D99
- Mean:
- >= 50.2 - <= 64.6 µm
- Remarks on result:
- other: 99.7& are <64.6µm, 98.2% are below 50.2%
- Remarks:
- batch 3
- Key result
- Percentile:
- other: 100%
- Mean:
- < 84.3 µm
- Remarks on result:
- other: consistent over three passages
- Percentile:
- D50
- Mean:
- 14.32 µm
- Remarks on result:
- other: batch 1
- Percentile:
- D50
- Mean:
- 18.84 µm
- Remarks on result:
- other: batch 2
- Percentile:
- D50
- Mean:
- 18.5 µm
- Remarks on result:
- other: batch 3
- Percentile:
- other: 99.7%
- Mean:
- < 50.2 µm
- Remarks on result:
- other: batch 1
- Percentile:
- other: 5.8%
- Mean:
- < 12.8 µm
- Remarks on result:
- other: batch 1
- Percentile:
- other: 98.7%
- Mean:
- < 50.2 µm
- Remarks on result:
- other: batch 2
- Percentile:
- other: 10.4%
- Mean:
- < 5.8 µm
- Remarks on result:
- other: batch 2
- Percentile:
- other: 98.2%
- Mean:
- < 50.2 µm
- Remarks on result:
- other: batch 3
- Percentile:
- other: 11%
- Mean:
- < 5 µm
- Remarks on result:
- other: batch 3
- Conclusions:
- The test was performed scientifically reasonable on three different bathces and was documented sufficiently. Hence, the results can be considered sufficiently reliable. Based on these results, 100% of the particles have the potential to be inhaled. Of these, approx. 99% may reach the thoracic region (according to ECHA's former guidance R7.C, 50µm) or approx. 25% (10µm, R7.C of July 2015), and of those of them,which may reach the alveoles, are approx. 50% or approx. 10%, dependent on the guidance.
- Executive summary:
The particle size of three different batches of the test item was performed by a Malvern Instruments Mastersizer laser particle sizer.
The maxima in the binodal distribution are at approximately 7 and 18 µm with mean particle sizes being calculated as 14.3, 18.8 and 18. 5 µm for batches 1,2,3, respectively.
Each of the samples of the test item show a significant spread of particle sizes, with an upper size limit being between 64 and 84 µm. At least 20% by weight of each of the samples are less than 10 µm in size.
Reference
Description of key information
The particle size of three different batches of the test item was performed by a Malvern Instruments Mastersizer laser particle sizer.
The maxima in the binodal distribution are at approximately 7 and 18 µm with mean particle sizes being calculated as 14.3, 18.8 and 18. 5 µm for batches 1,2,3, respectively.
Each of the samples of the test item show a significant spread of particle sizes, with an upper size limit being between 64 and 84 µm. At least 20% by weight of each of the samples are less than 10 µm in size.
Additional information
Based on these results, 100% of the particles have the potential to be inhaled. Of these, approx. 99% may reach the thoracic region (according to ECHA's former guidance R7.C, 50µm) or approx. 25% (10µm, R7.C of July 2015), and of those of them,which may reach the alveoles, are approx. 50% or approx 10%, dependent on the guidance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.