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EC number: 236-783-2 | CAS number: 13479-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- other: short communication
- Title:
- Sensitizing potential of beryllium, copper and molybdenum compounds studied by the guinea pig maximization method
- Author:
- A. Boman, J.E. Wahlberg, G Hagelthorn
- Year:
- 1 979
- Bibliographic source:
- Contact Dermatitis 1979 Vol. 5; Iss. 5
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
Test according to the principle of Magnusson & Kligman 1970.
- Short description of test conditions: Two groups of 20 animals were used for each metal compound. One group was actively sensitiactl and the other group (control was treated in the same way as the experimental group (Freund's complete adjuvant, petrolatum occlusion. etc.) except for the test compound. The groups were kept separately in plastic cages. challenged simultaneously and the readings performed blind.
- Parameters analysed / observed: Number of positive animals (as scored according to Magnusson & Kligman (1970)) for each concentration is given. - GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Copper sulphate
- EC Number:
- 231-847-6
- EC Name:
- Copper sulphate
- Cas Number:
- 7758-98-7
- Molecular formula:
- Cu.H2O4S
- Test material form:
- solid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Animals were kept in plastic cages, size was not reported. No further details on test animals and environmental conditions were given.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- petrolatum
- Concentration / amount:
- 0.01%
- Adequacy of induction:
- other: no information on concentration finding test, duration was also not reported
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 25%
- Adequacy of induction:
- other: no information on concentration finding tests, duration was not reported
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 1.0, 0.5, 0.1%
- Adequacy of challenge:
- other: no information on concentration finding tests, duration was not reported
- No. of animals per dose:
- 10
- Details on study design:
- No further details on study design reported
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 1% challenge concentration
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Remarks on result:
- positive indication of skin sensitisation
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 1% challenge concentration
- No. with + reactions:
- 7
- Total no. in group:
- 10
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The test described in the abstract of Boman et al., 1979, was conducted according to Magnusson & Kligman (1970). Groups of 10 guinea pigs were treated intradermally and epicutaneously with 0.01% and 25%, respectively. 21 days after the intradermal application the animals were challenged with 1.0, 0.5, and 0.1% copper sulphate solution in petrolatum. After 24 h (first reading 2 animals were scored positive for sensitisation and after 48h 7 animals were scored positive for skin sensitisation, thus, copper sulphate was regarded positive with respect to skin sensitisation.
- Executive summary:
The test described in the abstract of Boman et al., 1979, was conducted according to Magnusson & Kligman (1970). Groups of 10 guinea pigs were treated intradermally and epicutaneously with 0.01% and 25%, respectively. 21 days after the intradermal application the animals were challenged with 1.0, 0.5, and 0.1% copper sulphate solution in petrolatum. After 24 h (first reading) 2 animals were scored positive for sensitisation and after 48h 7 animals were scored positive for skin sensitisation, thus, copper sulphate was regarded positive with respect to skin sensitisation.
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