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EC number: 855-780-2 | CAS number: 3710-31-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June - July 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Study well performed but results for three female animals dosed at 2043 mg/kg bw only qualitatively reported, pre-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- study was based on draft OECD guideline
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- DL-hexane-1,2-diol
- EC Number:
- 230-029-6
- EC Name:
- DL-hexane-1,2-diol
- Cas Number:
- 6920-22-5
- IUPAC Name:
- hexane-1,2-diol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age of animals at start of test: Females 45-53 days, males 36-43 days
- Weight of animals at start of test: Females 0.127-0.169 kg, males 0.127-0.169 kg
- Source of animals: Hagemann, Externtal
- Acclimatisation prior to test: 10 days
- Animals used per dose: 5-10
- Animals used in total: 63
- Fasting period before start of the study: no food was supplied 16 hour prior to test start
- Housing: Animals were kept in groups of 5 in makrolon cages, type III
- Food: tandardized food (Altromin) was given and water ad libitum
- Room temperature: 21 ±2 °C
- Relative humidity: 50-60 %
- Light/dark cycle: 10 hour light/14 hours dark cycle per day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Volumina applied were 4.64-10.0 mg/kg bw for females and 2.15-10.0 mg/kg for male rats, equivalent to 4408-9500 mg/kg bw (females) respectively 2043-9500 mg/kg bw (males). The substance was applied pure and undiluted without vehicle by oral gavage.
- Doses:
- doses applied were 2043 mg/kg, 4408 mg/kg, 5339 mg/kg, 6470 mg/kg, 7838 mg/kg and 9500 mg/kg
- No. of animals per sex per dose:
- 3 males at 2043 mg/kg
5 males and 5 females at 4408 mg/kg
5 males and 5 females at 5339 mg/kg
5 males and 10 females at 6470 mg/kg
5 males and 10 females at 7838 mg/kg
10 females at 9500 mg/kg - Control animals:
- no
- Remarks:
- Control animals are not required.
- Details on study design:
- Observation period after test substance administration was 14 days
- Statistics:
- the LD50 was determined by Probit analysis for males and graphically for females.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 166 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 5 197 - <= 7 410
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 339 - <= 6 470
- Based on:
- test mat.
- Remarks on result:
- other: graphically determined
- Mortality:
- No mortality was observed at 2043 and 4408 mg/kg bw. At the dose of 6339 mg/kg mortality was observed (1 out of 5 males after 24 h and 3 out of 5 females at 0.5, 2 and 24 hours following exposure). At the highest dose (7838 mg/kg for males) 4 out of 5 animals died after 4 hours, respectively 5 out of 10 females at 9500 mg/kg (two 0.5 hours following exposure, one 2 hours after exposure and two 24 hours after exposure)
- Clinical signs:
- other: First signs of toxicity were reduction of muscular tonicity and effects on coordination capability, increasing with doses as aplied whereas mortality was described as general paralysis.
- Gross pathology:
- gross pathology revealed no substance specific effects in organs examined post mortem.
Any other information on results incl. tables
doses [mg/kg] | gender | mortality | 0.5 h | 1 h | 2 h | 4 h | 8 | 24 h | |
4408 | males | 0/5 | 0% | ||||||
6339 | males | 1/5 | 20% | 1 | |||||
6470 | males | 4/5 | 80% | 1 | 3 | ||||
7838 | males | 4/5 | 80% | 4 | |||||
4408 | females | 0/5 | 0% | ||||||
6339 | females | 3/5 | 60% | 1 | 1 | 1 | |||
6470 | females | 4/10 | 40% | 2 | 2 | ||||
7838 | females | 5/10 | 50% | 3 | 1 | 1 | |||
9500 | females | 5/10 | 50% | 2 | 1 | 2 |
results with 3 males dosed at 2043 mg/kg were not reported in value tables!
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 1,2-Hexanediol has an LD50, determined by OECD401 alike methodology, of 6166 mg/kg bw (males) respectively 5339-5470 mg/kg bw (females).
The value for males 6166 mg/kg bw, determined by probit analysis, is taken forward for hazard and risk assessment. - Executive summary:
In this study acute toxicity 1,2-hexanediol was investigated at high doses (4408 up to 9500 mg/kg bw). The LD50 was determined being greater 5000 mg/kg for male and female rats and thus outside boundaries for classification even under GHS (Globally Harmonized System for Classification and Labelling of Chemicals). Symptoms seen at concentrations as of 2043 mg/kg bw were reduced muscular tonicity and effects on coordination capability of animals. As only the LD50 for male rats was determined by probit analysis (LD50 of 6166 mg/kg bw), this value is considered being more reliable and taken forward for hazard and risk assessment.
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