Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 283-403-6 | CAS number: 84625-29-6 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Capsicum annuum, Solanaceae.
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: Supporting study. The LD50 of the test item is higher than 11250 mg/kg body weight by oral route in the rat.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5.0, 7.5 and 11.25 g/kg bw.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: not specified
- Necropsy of survivors performed: no specified
- Other examinations performed: clinical signs, body weight and time of death - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 11 250 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- no data
- Interpretation of results:
- other: Not classified (CLP Regulation EC no. 1272/2008)
- Conclusions:
- The LD50 of the test item is higher than 11250 mg/kg body weight by oral route in the rat.
- Executive summary:
The LD50 of the test item is higher than 11250 mg/kg body weight by oral route in the rat. At the dose of 11.25 g/kg bw, body weight gain was slightly suppressed, which was not observed at a dose of 5.0 or 7.5 g/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 11 250 mg/kg bw
- Quality of whole database:
- Supporting study with Klimisch score 4.
Additional information
Justification for classification or non-classification
Based on the available data, the substance is not classified for acute toxicity according to CLP Regulation (EC) no. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
